787632-66-0
中文名称
TDP-665759
英文名称
TDP-665759
CAS
787632-66-0
分子式
C31H34Cl2IN5O2
分子量
706.44
MOL 文件
787632-66-0.mol
结构式
基本信息
中文别名
化合物 T24861
英文别名
TDP-665759
TDP 665759
JNJ27291199
JNJ-27291199
JNJ 27291199
(3S)-4-[(1R)-1-(2-amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-1-[3-(4-methylpiperazin-1-yl)propyl]-3H-1,4-benzodiazepine-2,5-dione
TDP 665759
JNJ27291199
JNJ-27291199
JNJ 27291199
(3S)-4-[(1R)-1-(2-amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-1-[3-(4-methylpiperazin-1-yl)propyl]-3H-1,4-benzodiazepine-2,5-dione
物理化学性质
| 沸点 | 835.4±65.0 °C(Predicted) |
| 密度 | 1.484±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 7.66±0.10(Predicted) |
应用领域
用途一
TDP665759 is an inhibitor of the Hdm2:p53 complex. It acts by suppressing human tumor cell proliferation in vitro and sensitizing tumors to doxorubicin in vivo.