73360-56-2
基本信息
氯硝柳胺 一水合物
5-氯-N-(2-氯-4-硝基苯基)-2-羟基苯甲酰胺一水合物
Cestocide
2',5-D733ichloro-4'-nitrosalicylanilide Hydrate
N-(2-Chloro-4-nitrophenyl)-5-chlorosalicylaMide Hydrate
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzaMide Hydrate
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate
物理化学性质
| 熔点 | 224-229℃ |
| 储存条件 | -20°C储存 |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | neat |
安全数据
| 危险性符号(GHS) |  GHS09 |
| 警示词 | 警告 |
| 危险性描述 | H400 |
| 防范说明 | P273 |
| 危险品标志 | N |
| 危险类别码 | 50 |
| 安全说明 | 61 |
| 危险品运输编号 | UN 3077 9 / PGIII |
| WGK Germany | 2 |
| RTECS号 | VN8400000 |
常见问题列表
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STAT3 0.25 μM (IC 50 , in HeLa cells) |
Niclosamide monohydrate is an inhibitor of STAT3, inhibits STAT3-mediated luciferase reporter activity with an IC 50 of 0.25 μM in HeLa cells. Niclosamide (1 μM) inhibits the EGF-induced nuclear translocation of STAT3 in Du145 cells. Niclosamide (< 2 μM) dose dependently inhibits the transcription of STAT3 downstream genes in Du145 cells. Niclosamide (< 10 μM) induces G0/G1 arrest and apoptosis of Du145 cancer cells in a dose dependent manner. Niclosamide can block SARS-CoV replication at a micromolar concentration in Vero E6 cells infected with SARS-CoV. Niclosamide (< 7.5 μM) promotes Frizzled1 endocytosis, downregulates Dishevelled-2 protein, and inhibits Wnt3A-stimulated beta-catenin stabilization and LEF/TCF reporter activity in U2OS cells. Niclosamide inhibits the TNF-induced NF-κB reporter activity in a dose- and time-dependent manner in U2OS cells. Niclosamide (125 nM) inhibits NF-κB activation induced by p65, IKKα, IKKβ, IKKγ, and TAK1 in U2OS cells. Niclosamide (< 500 nM) completely block the time- and dose-dependent TNFα-induced alteration of the NF-κB-DNA complex in HL-60 cells. Niclosamide (< 10 nM) inhibits constitutive NF-κB activation in U266 cells. Niclosamide inhibits TNF-induced degradation of IκBα and relocation of p65 in a dose- and time-dependent manner in HL-60, Molm13, or AML primary cells. Niclosamide (500 nM) causes decrease in TNF-induced NF-κB-dependent gene products involved in cell survival in HL-60 cells. Niclosamide also inhibits the growth and induces robust apoptosis of AML cells associated with decreased Mcl-1 and XIAP levels and increased intracellular ROS levels.
Niclosamide (40 mg/kg/d, i.p.) suppresses growth of xenografted AML cells in nude mice bearing HL-60 xenograft tumors.