68506-86-5
基本信息
4-氨基己-5-烯酸
(+/-)-Vigabatrin
SABRIL
Γ-VINYL-GABA
5-Hexenoic acid, 4-amino-
(±)-4-aminohex-5-enoic acid
Vigabatrin, racemic mixture
rac-VigabatrinDiscontinued See V253010
Vigabatrin hydrochloride salt, racemic mixture
物理化学性质
| 熔点 | 209℃ |
| 沸点 | 277.7±28.0 °C(Predicted) |
| 密度 | 1.064±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 少许溶于甲醇和水 |
| 酸度系数(pKa) | 4.36±0.10(Predicted) |
| 形态 | neat |
| 颜色 | 米白色 |
| 水溶解性 | 溶于水至100mM |
| 主要应用 | pharmaceutical pharmaceutical small molecule |
| InChI | 1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) |
| InChIKey | PJDFLNIOAUIZSL-UHFFFAOYSA-N |
| SMILES | NC(CCC(O)=O)C=C |
安全数据
| 危险性符号(GHS) |  GHS08 |
| 警示词 | 危险 |
| 危险性描述 | H372 |
| 防范说明 | P260-P264-P270-P314-P501 |
| 危险品标志 | Xi |
| 危险类别码 | 36/37/38 |
| 安全说明 | 26-36 |
| WGK Germany | 3 |
| RTECS号 | MP7745000 |
| 海关编码 | 2922498050 |
| 存储类别 | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| 危险性类别 | STOT RE 1 |
| 毒害物质数据 | 68506-86-5(Hazardous Substances Data) |
| 毒性 | LD50 oral in rat: 3gm/kg |
4-氨基己-5-烯酸价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/06/05 | HY-15399R | 4-氨基己-5-烯酸 Vigabatrin (Standard) | 68506-86-5 | 5 mg | 1250元 |
| 2026/06/05 | HY-15399R | 4-氨基己-5-烯酸 Vigabatrin (Standard) | 68506-86-5 | 10 mg | 2000元 |
| 2026/06/05 | HY-15399R | 4-氨基己-5-烯酸 Vigabatrin (Standard) | 68506-86-5 | 25 mg | 4000元 |
常见问题列表
A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin.
Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models.