64821-19-8
中文名称
化合物MAO-IN-M30二盐酸盐
英文名称
VAR10300 dihydrochloride
CAS
64821-19-8
分子式
C14H16Cl2N2O
分子量
299.196
MOL 文件
64821-19-8.mol
更新日期
2024/06/22 07:11:29
结构式
![64821-19-8 结构式](https://www.chemicalbook.com/CAS/20180906/GIF/64821-19-8.gif)
基本信息
中文别名
化合物MAO-IN-M30二盐酸盐
英文别名
M30 dihydrochloride
M-30 dihydrochloride
VAR10300 dihydrochloride
MAO-IN-M30 dihydrochloride
5-[[Methyl(2-propyn-1-yl)amino]methyl]-8-quinolinol Dihydrochloride
5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride
N-(8-Hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine dihydrochloride
M-30 dihydrochloride
VAR10300 dihydrochloride
MAO-IN-M30 dihydrochloride
5-[[Methyl(2-propyn-1-yl)amino]methyl]-8-quinolinol Dihydrochloride
5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride
N-(8-Hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine dihydrochloride
物理化学性质
储存条件 | 2-8°C |
溶解度 | DMSO、庚烷和二甲苯:≥21mg/mL |
形态 | 粉末 |
颜色 | 黄绿色 |
水溶解性 | 溶于水至100mM |
安全数据
危险性符号(GHS) | ![]() ![]() GHS05,GHS07 |
警示词 | 危险 |
危险性描述 | H302-H318 |
防范说明 | P280-P301+P312+P330-P305+P351+P338+P310 |
危险品标志 | Xn |
危险类别码 | 22-41 |
安全说明 | 26-39 |
WGK Germany | 3 |
常见问题列表
生物活性
MAO-IN-M30 dihydrochloride 是一种口服活性,可通过血脑屏障的,脑选择性不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。
靶点
MAO-A 37 nM (IC 50 ) |
MAO-B 57 nM (IC 50 ) |
体外研究
MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone.
MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival.
MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells.
Cell Viability Assay
Cell Line: | SH-SY5Y cells |
Concentration: | 0.25 nM |
Incubation Time: | 72 hours |
Result: | Significantly increased cell viability to ∼90% after exposure to Dexamethasone. |
Cell Viability Assay
Cell Line: | PC12 cells |
Concentration: | 0-10 μM |
Incubation Time: | 24 hours |
Result: | Enhanced the PC12 cell viability, the cell viability increasing to 85 ± 6 and 90 ± 7%. |
体内研究
MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities.
Animal Model: | Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice) |
Dosage: | 0.5, 2.5 mg/kg |
Administration: | P.o.; once daily for 14 consecutive days |
Result: | Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc. |
供应商信息 更多
苏州致信生物科技有限公司
现货
联系电话:
0512-65118909 15162312715
产品介绍:
英文名称:MAO-IN-M30dihydrochloride
CAS:64821-19-8
纯度:98%+
包装信息:1g;10g;100g
库存量:
1g
现货日期:
2024/6/22 7:11:29
常州辰鸿生物科技有限公司
联系电话:
0519-85788828 13775037613
产品介绍:
英文名称:MAO-IN-M30 dihydrochloride
CAS:64821-19-8
纯度:99%
包装信息:50mg;100mg;250mg;500mg;1g;5g
天津普西唐生物医药科技有限公司
联系电话:
010-60605840
产品介绍:
英文名称:MAO-IN-M30 dihydrochloride
CAS:64821-19-8
纯度:98%
包装信息:5mg
广东翁江化学试剂有限公司
联系电话:
0751-2815987 13927875076
产品介绍:
中文名称:化合物MAO-IN-M30二盐酸盐
英文名称: MAO-IN-M30 dihydrochloride
CAS:64821-19-8
纯度:>=98.0%
包装信息:5mg
TargetMol中国(陶术生物)
联系电话:
4008200310
产品介绍:
中文名称:化合物MAO-IN-M30二盐酸盐
英文名称:MAO-IN-M30 dihydrochloride
CAS:64821-19-8
纯度:98.43%
包装信息:1 mg;10 mg;100 mg;2 mg;25 mg;5 mg;50 mg
上海阿拉丁生化科技股份有限公司
联系电话:
+86-18521732826
产品介绍:
中文名称:M 30 二盐酸盐
英文名称:M 30 dihydrochloride
CAS:64821-19-8
纯度:>=98%(HPLC)
包装信息:25mg/RMB 4239.90;5mg/RMB 1088.90;10mg/RMB 1879.90
銳迪國際科技有限公司
联系电话:
18024082417
产品介绍:
英文名称:MAO-IN-M30 dihydrochloride
CAS:64821-19-8
纯度:5mg;10mg;50mg;100mg;250mg;500mg;1g
包装信息:5mg;10mg;50mg;100mg;250mg;500mg;1g