6090-95-5
基本信息
1,2-脱水肌醇
环己烯四醇Β环氧化物(脱水肌醇)
conduritolepoxide
CONDURITOL B EPOXIDE
1,2-Anhydro-myo-inositol
Myo-Inositol,1,2-anhydro-
(+/-) CONDURITOL B EPOXIDE
Conduritol B Epoxide (CBE)
DL-1,2-ANHYDRO-MYO-INOSITOL
myo-Inositol, 1,2-anhydro- (9CI)
4h-3,1-benzoxazin-4-one, 5-methyl-2-(3-nitrophenyl)-
物理化学性质
| 熔点 | 157-159 |
| 沸点 | 360.5±42.0 °C(Predicted) |
| 密度 | 1.925±0.06 g/cm3 (20 ºC 760 Torr) |
| 储存条件 | 2-8°C |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于水（高达25mg/ml）或DMSO |
| 酸度系数(pKa) | 13.08±0.70(Predicted) |
| 形态 | 白色固体 |
| 颜色 | 白色 |
| 生物来源 | synthetic (organic) |
| 水溶解性 | water: 20mg/mL, clear, colorless to faintly yellow |
| 稳定性 | 湿气敏感 |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H315-H319-H335 |
| 防范说明 | P261-P271-P280 |
| WGK Germany | 3 |
| WGK Germany | 3 |
| Hazard Note | Harmful |
| 海关编码 | 2932990090 |
1,2-脱水肌醇价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-100944 | 1,2-脱水肌醇 Conduritol B epoxide | 6090-95-5 | 1 mg | 250元 |
| 2025/02/08 | HY-100944 | 1,2-脱水肌醇 Conduritol B epoxide | 6090-95-5 | 5mg | 550元 |
| 2025/02/08 | HY-100944 | 1,2-脱水肌醇 Conduritol B epoxide | 6090-95-5 | 10mM * 1mLin DMSO | 605元 |
常见问题列表
Treating N2a and Conduritol B epoxide-N2a cells with G6 gave GC reductions to 7% and 26% of untreated levels, respectively. G6 treated Conduritol B epoxide-N2a also has significantly decreased GS. Co-treatment of G6 and dantrolene of Conduritol B epoxide-N2a cells lead to a similar degree of GC and GS reduction as G6 alone, indicating a specific effect of G6 on inhibition of substrate accumulation, Conduritol B epoxide-N2a cells have higher calcium levels than in N2a cells without caffeine at baseline. Conduritol B epoxide-N2a cells show a significant increase in cytosolic calcium levels compared to N2a cells. Conduritol B epoxide-N2a cells show a significant reduction in OCR as evidenced by approximately 50% in all the parameters, including rate of ATP production, basal respiration, and maximal respiration, compared to N2a cells, indicating reduced mitochondrial function in this nGD cell model. In dantrolene-treated Conduritol B epoxide-N2a cells, levels of Ryr3 are increased to 76% of WT level.
Conduritol B epoxide treatment of 4L, 9H, 9V and WT mice (100 mg/kg/day, i.p.) from postnatal day 5 to 11 does not induce α-synuclein aggregates. Long-term daily Conduritol B epoxide treatment of 4L mice (100 mg/kg/day of Conduritol B epoxide from postnatal day 15 for 24 or 36 doses) leads to hind limb paralysis and small amounts of α-synuclein accumulation in the olfactory bulb, brainstem, and PVP near D3V (dorsal 3rd ventricle).