50-49-7

基本信息

物理化学性质

熔点	174°C
沸点	bp0.1 160°
密度	0.9935 (rough estimate)
折射率	1.5640 (estimate)
酸度系数(pKa)	pKa 9.66(H2O,t = 25,I=0.025) (Uncertain)
水溶解性	18.23mg/L(24 ºC)
Concentration	1 mCi/ml
Solvent	Ethanol under nitrogen
Specific Activity	60-90 Ci/mmol
BCS Class	1
EPA化学物质信息	Imipramine (50-49-7)

安全数据

危险性符号(GHS)	GHS07,GHS08
警示词	危险
危险性描述	H302-H336-H370-H400
防范说明	P261-P280-P305+P351+P338-P304+P340-P271-P312-P405-P403+P233-P260-P264-P270-P307+P311-P321-P405-P501-P391
毒害物质数据	50-49-7(Hazardous Substances Data)
毒性	A tertiary amine tricyclic antidepressant that is thought to exert its therapeutic effect by inhibiting the reuptake of serotonin and norepinephrine centrally. A major metabolite is N-desmethylimipramine (desipramine), also used as an antidepressant drug. Desipramine differs from imipramine in being a better blocker of norepinephrine, rather than serotonin, uptake. Side effects, including sedation and drowsiness, dry mouth, urinary retention, constipation, and orthostatic hypotension, are probably due to the anticholinergic, anti-α-adrenergic, and antihistaminergic receptor-blocking properties. Imipramine should not be used in conjunction with a monoamine oxidase inhibitor or other treatment that increases catecholamine concentrations (e.g., drugs containing sympathomimetic amines). Imipramine should be avoided in patients with cardiovascular disease or seizure disorder, or in those who may abuse alcohol, as imipramine lowers seizure threshold, can produce cardiovascular toxicity and may potentiate the effects of alcohol. Imipramine intoxication can include CNS abnormalities (e.g., drowsiness, stupor, coma, and extrapyramidal symptoms), cardiac arrhythmia, and respiratory depression. Children appear to be particularly vulnerable to the cardiotoxic and seizure-inducing effects of high doses of imipramine. The oral LD50 in female rats is 305 mg/kg.

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