113-52-0
基本信息
盐酸丙咪嗪
丙咪嗪
咪帕明
托弗尼尔
丙咪嗪盐酸
丙咪嗪盐酸盐
10,11-DIHYDRO-N,N-DIMETHYL-5H-DIBENZ[B,F]AZEPINE-5-PROPANAMINE HYDROCHLORIDE
10,11-DIHYDRO-N,N-DIMETHYL-DIBENZ[B,F]AZEPINE-5-PROPANAMINE HYDROCHLORIDE
IMIPRAMINE HCL
IMIPRAMINE HYDROCHLORIDE
LABOTEST-BB LT00452014
10,11-Dihydro-N,N-dimithyl-5,H-dibenz[b,f]azepine-5-propanamine
5-(3-dimethylaminopropyl)-10,11-dihydro-5h-dibenz(b,f)azepinehydrochloride
5H-dibenz[b,f]azepine,5-[3-(dimethylamino)propyl]-10,11-dihydro-,monohydrochloride
antideprinhydrochloride
chimoreptin
chrytemin
cocapimipramine25
deprinol
dynazina
efuranol
f)azepine,10,11-dihydro-5-(3-(dimethylamino)propyl)-5h-dibenz(hydrochlor
f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-5h-dibenz(monohydrochl
f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-5h-dibenz(monohydrochloride
f)azepine-5-propanamine,10,11-dihydro-n,n-dimethyl-5h-dibenz(monohydroch
物理化学性质
外观性状 | 白色或类白色结晶性粉末,无臭或几乎无臭,遇光渐变色。 |
溶解性 | 在水,乙醇或三氯甲烷中易溶,在乙醚中几乎不溶。 |
熔点 | 168-1700C |
闪点 | 9℃ |
储存条件 | 2-8°C |
储存条件 | 2-8°C |
溶解度 | H2O: 50 mg/mL |
溶解度 | H2O:50 mg/mL |
形态 | crystalline |
形态 | crystalline |
颜色 | white |
颜色 | 白色 |
PH值 | 4.2~5.2(100g/l,25℃) |
水溶解性 | 溶于水 |
最大波长(λmax) | 260nm(lit.) |
Merck | 13,4943 |
Merck | 14,4920 |
质量标准 | 中国药典2000;BP2003;EP4;JP14;USP27 |
CAS 数据库 | 113-52-0(CAS DataBase Reference) |
EPA Substance Registry System | 113-52-0(EPA Substance) |
EPA化学物质信息 | 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride (113-52-0) |
药理作用 | 盐酸丙咪嗪(113-52-0)为三环类抗抑郁药,适用于治疗迟缓性的内因性抑郁症。主要作用在于阻断中枢神经系统对去甲肾上腺素和5-羟色胺这二种神经递质的再摄取,从而使突触间隙中这二种神经递质浓度增高,发挥抗抑郁作用。盐酸丙咪嗪(113-52-0)还有抗胆碱,抗1肾上腺素受体及抗H1组胺受体作用,但对多巴胺受体影响甚小。 |
安全数据
危险性符号(GHS) | GHS06 |
警示词 | 危险 |
危险性描述 | H300 |
防范说明 | P264-P270-P301+P310-P405-P501 |
危险品标志 | Xn,T,F |
危险品标志 | Xn |
危险类别码 | 23/25-36/38-36/37/38-22 |
危险类别码 | 23/25-36/38-36/37/38-22-39/23/24/25-23/24/25-11 |
安全说明 | 7-16-24-33-45-36-26 |
安全说明 | 7-16-24-33-45-36-26-36/37 |
危险品运输编号 | UN 1230 3/PG 2 |
危险品运输编号 | UN 1230 3/PG 2 |
WGK Germany | 3 |
WGK Germany | 3 |
RTECS号 | HO1925000 |
TSCA | Yes |
海关编码 | 2933995800 |
毒性 | LD50 in mice, rats (mg/kg): 400, 490 orally; 110, 90 i.p. (Tobe) |
应用领域
制备方法
盐酸丙咪嗪价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/08/19 | I0971 | 丙咪嗪盐酸盐 Imipramine Hydrochloride | 113-52-0 | 250MG | 190元 |
2024/08/19 | I0971 | 丙咪嗪盐酸盐 Imipramine Hydrochloride | 113-52-0 | 1g | 485元 |
2024/08/19 | HY-B1490 | 盐酸丙咪嗪 Imipramine hydrochloride | 113-52-0 | 100mg | 500元 |
常见问题列表
IC50: 32 nM (serotonin)
Depression-like behavior is often complicated by chronic pain. Antidepressants including imipramine are widely used to treat chronic pain, but the mechanisms are not fully understood. Imipramine (IC 50 =32 nM) and desipramine (IC 50 =160 nM) are found to be potent inhibitors of the human placental serotonin transporter.
Administration of imipramine reverses social avoidance behavior, significantly increasing the interaction time. 24 days of imipramine treatment in RSD mice significantly decreases stress-induced mRNA levels for IL-6 in brain microglia. Chronic mild stress induces a long-term altered gene expression profile in the prefrontal cortex that is partially reverted by imipramine treatment (10mg/kg, i.p.). Chronic imipramine administration alteres the amino acid dynamics in the brain. In the striatum, the concentrations of asparagine, glutamine and methionine are significantly increased by chronic imipramine administration. In the thalamus and hypothalamus, chronic imipramine administration significantly decreased the valine concentration. Imipramine reduces pain-related negative emotion without influencing pain and that this effect is diminished by denervation of 5-HT neurons and by anti-BDNF treatment. Imipramine also normalizes derangement of ERK/CREB coupling, which leads to induction of BDNF. This suggests a possible interaction between 5-HT and BDNF. Imipramine treatment counteracts the corticosterone administration-induced increase in the reactivity of rat CA3 hippocampal circuitry to the activation of the 5-HT receptor.