328069-91-6
中文名称
化合物 MT477
英文名称
MT477
CAS
328069-91-6
分子式
C31H30N2O12S3
分子量
718.77
MOL 文件
328069-91-6.mol
结构式
基本信息
中文别名
化合物 MT477
英文别名
MT477
tetramethyl 6'-[(2,5-dioxopyrrolidin-1-yl)acetyl]-7'-methoxy-5',5'-dimethyl-5',6'-dihydrospiro[1,3-dithiole-2,1'-thiopyrano[2,3-c]quinoline]-2',3',4,5-tetracarboxylate
tetramethyl 6'-[(2,5-dioxopyrrolidin-1-yl)acetyl]-7'-methoxy-5',5'-dimethyl-5',6'-dihydrospiro[1,3-dithiole-2,1'-thiopyrano[2,3-c]quinoline]-2',3',4,5-tetracarboxylate
物理化学性质
| 沸点 | 916.0±65.0 °C(Predicted) |
| 密度 | 1.55±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | -6.45±0.70(Predicted) |
应用领域
用途一
MT477 is PKC-α inhibitor. MT477 interfered with PKC activity as well as phosphorylation of Ras and ERK1/2 in H226 human lung carcinoma cells. It also induced poly-caspase-dependent apoptosis. MT477 had a dose-dependent (0.006 to 0.2 mM) inhibitory effect on cellular proliferation of H226, MCF-7, U87, LNCaP, A431 and A549 cancer cell lines as determined by in vitro proliferation assays.
常见问题列表
概述
MT477 是一种有效的蛋白激酶 C (protein kinase C (PKC)) 抑制剂。MT477 可诱导细胞凋亡 (apoptosis) 和坏死 (necrosis)。MT477 可降低 Ras-GTP、p-Erk1/2、p-Elk1 的蛋白表达。MT477 具有抗肿瘤活性。