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65271-80-9

供应商 相关产品 基本信息 物理化学性质 理化性质 应用领域 安全数据 米托蒽醌价格(试剂级) 常见问题列表

产品图片

基本信息

英文
Mitoxantrone
中文
米托蒽醌
英文名称
1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]-anthracene-9,10-dione
MITOXANTRONE
1,4-dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedi
5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxy-anthraquinon
5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxyanthraquinone
9,10-anthracenedione,1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)a
dihydroxyanthraquinone
mitoxanthrone
nsc279836
MitoxantroneBase
Mitoxantrone Hcl 70476-82-3 / Base
PharmasubstanceEP4
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione
NSC-27983
9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-
1,4-dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthrace nedimitoxantrone
MITOXANTRONUM AND THE INTERMEDIATES
Mitoxantrone (base and/or unspecified salts)
MITOXANTRONUM
1,4-Dihydroxy-5,8-bis[2-[(2-hydroxyethyl)amino]ethylamino]-9,10-anthraquinone
CAS
65271-80-9
中文名称
1,4-二羟基-5,8-双[[2-[(2-羟乙基)氨基]乙基]氨基]-9,10-蒽醌
米托蒽醌
米托恩醌
分子式
C22H28N4O6
MDL 编号
MFCD00242942
分子量
444.48
MOL 文件
65271-80-9.mol

物理化学性质

外观性状
蓝黑色结晶。熔点203-205℃。略溶于水,微溶于乙醇,不溶于氯仿和丙酮。无臭,易吸潮
熔点 
170-1740C

理化性质

沸点 
554.47°C (rough estimate)
密度 
1.3049 (rough estimate)
折射率 
1.6500 (estimate)
储存条件 
Keep in dark place,Sealed in dry,2-8°C
酸度系数(pKa)
pKa 5.99 (Uncertain);8.13 (Uncertain)
CAS 数据库
65271-80-9(CAS DataBase Reference)
(IARC)致癌物分类
2B (Vol. 76) 2000

应用领域

用途一
蒽环类抗癌药,抗癌活性与阿霉素相似或略高,明显高于环磷酰胺、阿糖胞苷、甲氨喋呤、氟脲嘧啶、长春新碱等常用的抗癌药。临床用于乳腺癌有突出的疗效。

安全数据

危险品标志 
T
危险类别码 
R46-R61
安全说明 
S53-S36/37/39-S45
WGK Germany 
3

RTECS 
CB5748500

RTECS号
CB5748500

米托蒽醌价格(试剂级)

米托蒽醌价格(试剂级)
更新日期产品编号产品名称包装价格
2021/09/07M3133米托蒽醌
Mitoxantrone
200mg1090元
2021/09/07M3133米托蒽醌
Mitoxantrone
1g3290元

常见问题列表

生物活性
Mitoxantrone是拓扑异构酶II (topoisomerase II)的抑制剂;也可抑制蛋白激酶C (PKC), IC50值为8.5 μM。
靶点

PKC

8.5 μM (IC 50 )

Topoisomerase II


体外研究

Mitoxantrone inhibits PKC in a competitive manner with respect to histone H1, and its K i value is 6.3 μM and in a non-competitive manner with respect to phosphatidylserine and ATP. Treatment of B-CLL cells for 48 h with mitoxantrone (0.5 μg/mL) induces a decrease in cell viability. Mitoxantrone induces DNA fragmentation and the proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), demonstrating that the cytotoxic effect of mitoxantrone is due to induction of apoptosis. Mitoxantrone shows cytotoxicity to human breast carcinoma cell lines MDA-MB-231 and MCF-7 with IC 50 values of 18 and 196 nM, respectively.


体内研究

Mitoxantrone given IP at the optimal dose (1.6 mg/kg/day; as a free base) produces a statistically significant number of 60-day survivors (curative effect) in mice with IP implanted L1210 leukemia. In SC implanted Lewis lung carcinoma, mitoxantrone and ADM administered IV also shows effective antitumor activities and produces a 60% and a 45% ILS, respectively..


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