257879-35-9
基本信息
PKCβ Inhibitor
PKCβ inhibitor 1
3-anilino-4-[1-(3-imidazol-1-ylpropyl)indol-3-yl]pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-[1-[3-(1H-imidazol-1-yl)propyl]-1H-indol-3-yl]-4-(phenylamino)-
物理化学性质
| 溶解度 | DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.25 mg/ml |
| 形态 | 固体 |
| 颜色 | Yellow to orange |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H315-H319-H335 |
| 防范说明 | P261-P305+P351+P338 |
3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-13335 | 3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮 PKCβ inhibitor 1 | 257879-35-9 | 500μg | 1100元 |
| 2024/11/08 | HY-13335 | 3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮 PKCβ inhibitor 1 | 257879-35-9 | 1mg | 1800元 |
| 2024/11/08 | HY-13335 | 3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮 PKCβ inhibitor 1 | 257879-35-9 | 5mg | 5200元 |
常见问题列表
|
human PKCβ1 21 nM (IC 50 ) |
human PKCβ2 5 nM (IC 50 ) |
PKCα 331 nM (IC 50 ) |
PKCβ inhibitor 1 (0-30 μM; 48 hours) suppresses tumor cell proliferation in a time- and dose-dependent manner.
PKCβ inhibitor 1 (14 μM; 2-48 hours) induces apoptosis in 2F7 cells.
PKCβ inhibitor 1 (15 μM; 2-48 hours) inhibits cell cycle progression in 2F7 and BCBL-1 cells.
PKCβ (15 or 14 μM, respectively; 2-48 hours) inhibitor 1 reduces the expression of phospho-PKCβ in BCBL-1 and 2F7 cells.
PKCβ inhibitor 1(0-48 hours) suppresses GSK3β, mTOR, and S6 phosphorylation.
Cell Proliferation Assay
| Cell Line: | 2F7, BCBL-1 cells |
| Concentration: | 0, 5, 10, 20, and 30 μM |
| Incubation Time: | 48 hours |
| Result: | A dose-dependent reduction in viability of the 2F7 and BCBL-1 cells starting at 5 μM and increasing with elevated inhibitor concentration. |
Apoptosis Analysis
| Cell Line: | 2F7 cells |
| Concentration: | 14 μM |
| Incubation Time: | 2-48 hours |
| Result: | Apoptotic induction in 2.1% of the 2F7 cells above background after 2 hours of treatment, increasing through 48 hours of treatment. |
Cell Cycle Analysis
| Cell Line: | BCBL-1 Cells |
| Concentration: | 15 μM (the IC 50 ) |
| Incubation Time: | 2-48 hours |
| Result: | Inhibits cell cycle progression in 2F7 and BCBL-1 cells. |
Western Blot Analysis
| Cell Line: | BCBL-1 and 2F7 cell lines |
| Concentration: | 15 or 14 μM (at the IC 50 respectively) |
| Incubation Time: | 2-48 hours |
| Result: | The expression of phospho-PKCβ in BCBL-1 and 2F7 cells reduced. |