2320261-63-8
结构式
物理化学性质
| 溶解度 | Ethanol: 0.3 mg/ml; PBS (pH 7.2): 2.5 mg/ml |
| 形态 | A crystalline solid |
应用领域
用途一
AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. Note: AEW541 has a Cis-configuration on the cyclobutane ring. Its CAS# is 475489-16-8. Many vendors and Sc-finder scholar made mistake - AEW541 was mistakenly listed as CAS#475488-34-7, the trans-isomer of AEW541. The correct structure of AEW541 can be confirmed from Joel Slade, et al (from Novartis), Org. Process Res. Dev. 2007, 11, 5, 825–835.
常见问题列表
概述
NVP-AEW541 dihydrochloride (AEW541 dihydrochloride) 是一种具有口服活性的胰岛素样生长因子1受体 (IGF-1R) 的抑制剂，IC50 值为 0.15 μM。NVP-AEW541 dihydrochloride 也抑制 InsR，IC50 值为 0.14 μM。NVP-AEW541 dihydrochloride 具有抗肿瘤活性。
供应商信息 更多
ChemeGen 中国
联系电话：
18818260767
产品介绍：
英文名称：NVP-AEW541 hydrochloride
CAS：2320261-63-8
纯度：98%
包装信息：10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注：品牌：ChemeGen
TargetMol中国（陶术生物）
联系电话：
4008200310 15002144251
产品介绍：
中文名称：化合物 AEW541 HCl
英文名称：AEW541 HCl
CAS：2320261-63-8
包装信息：1mg/RMB 2870;5mg/RMB 10900;10mg/RMB 19200
上海一飞生物科技有限公司
联系电话：
021-65675885 18964387627
产品介绍：
英文名称：NVP-AEW541 (hydrochloride)
CAS：2320261-63-8
纯度：98%
包装信息：500μg;1mg;5mg
备注：试剂级