231957-54-3
基本信息
MIV-150
MIV150,MIV 150
1-(5-cyanopyridin-2-yl)-3-[(1S,2S)-2-(6-fluoro-2-hydroxy-3-
物理化学性质
| 沸点 | 501.8±50.0 °C(Predicted) |
| 密度 | 1.41±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | DMF: 30 mg/mL; DMSO: 30 mg/mL; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL; Ethanol: 0.25 mg/mL |
| 酸度系数(pKa) | 7.49±0.50(Predicted) |
| 形态 | 结晶固体 |
常见问题列表
|
HIV-1 <1 nM (EC 50 ) |
HIV-2 <1 nM (EC 50 ) |
The activity of MIV-150 to protect target cells from infection is assayed using a syncytial assay. The EC 50 of MIV-150 against HIV-1MN in CEM.SS cells is below 1 nM. These data are in agreement with the findings of Medivir. MIV-150 effectively inactivated free virus with an EC 50 of 0.004 μg/mL (or 0.01 μM). It is demonstrated MIV-150 is highly effective against HIV and that the drug blocks viruses that are resistant to other marketed HIV antiretrovirals such as Nevirapine, Delavirdine, and Efavirenz. In addition, resistance to MIV-150 develops more slowly than to other anti-HIV drugs tested. For example, in vitro studies demonstrate that resistance development in the presence of nevirapine and delavirdine takes only 4 to 5 weeks compared with 45 weeks in the presence of MIV-150.