209969-60-8
中文名称
化合物 T27269
英文名称
2H-1-Benzopyran-2-one, 7-methoxy-6-[3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy]-3,4-dimethyl-, hydrochloride (1:1)
CAS
209969-60-8
分子式
C26H33ClN2O5
分子量
489.01
MOL 文件
209969-60-8.mol
结构式
基本信息
中文别名
化合物 T27269
英文别名
KA672
KA 672
KA-672 HCl
Ensaculin HCl
Anseculin Hydrochloride
2H-1-Benzopyran-2-one, 7-methoxy-6-[3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy]-3,4-dimethyl-, hydrochloride (1:1)
KA 672
KA-672 HCl
Ensaculin HCl
Anseculin Hydrochloride
2H-1-Benzopyran-2-one, 7-methoxy-6-[3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy]-3,4-dimethyl-, hydrochloride (1:1)
应用领域
用途一
Ensaculin, also known as KA-672, is a NMDA antagonist and a 5HT1A agonist potentially for the treatment of Alzheimer's disease (AD). Ensaculin showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and artificially amnesic rodents. It exhibited neuroprotective activities in an NMDA toxicity model and neurotrophic effects in primary cultured rat brain cells. In receptor-binding studies, ensaculin was found to have high affinities to serotonergic 5-HT(1A) and 5-HT(7) receptors, adrenergic alpha(1), and dopaminergic D(2) and D(3) receptors.
常见问题列表
概述
Ensaculin 是一种 NMDA 受体通道阻滞剂。Ensaculin 在 NMDA 毒性模型中具有神经保护活性，在原代培养的大鼠脑细胞中具有神经营养作用。Ensaculin 具有作为作用于多种神经递质系统的抗痴呆药物的潜力。