18444-66-1
基本信息
葫芦素 E
葫芦素E对照品
葫芦素E(标准品)
葫芦素E(葫芦苦素E)
葫芦素 E, >99%
葫芦素 E, 来源于甜瓜
A-ELATERIN
Cucurbit E
α-Elaterine
CUCURBITACIN E
ALPHA-ELATERIN
cucurbitacine-e
alpha-elaterine
CUCURBITACIN E(SH)
CUCURBITACIN E hplc
物理化学性质
外观性状 | 白色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于甜瓜蒂。 |
熔点 | 228-234°C |
比旋光度 | D -59° (c = 0.7 in chloroform) |
沸点 | 545.56°C (rough estimate) |
密度 | 1.1059 (rough estimate) |
折射率 | 1.4900 (estimate) |
储存条件 | -20°C |
溶解度 | DMSO:可溶15mg/mL,澄清 |
酸度系数(pKa) | 8.51±0.70(Predicted) |
形态 | 粉末 |
颜色 | 白色至米色 |
旋光性 (optical activity) | [α]/D -60 to -75°, c = 0.7 (CDCl3) |
InChIKey | NDYMQXYDSVBNLL-MUYMLXPFSA-N |
LogP | 3.150 (est) |
安全数据
危险性符号(GHS) | GHS07 |
警示词 | 警告 |
危险性描述 | H302 |
防范说明 | P301+P312+P330 |
危险品标志 | Xn |
危险类别码 | 25-22 |
安全说明 | 1-22-45-24/25 |
危险品运输编号 | 3172 |
WGK Germany | 3 |
RTECS号 | RC6305500 |
海关编码 | 29153900 |
毒性 | LD50 orally in mice: 340 mg/kg (Albert) |
应用领域
药理药效:用于治疗慢性肝炎。1细胞毒与抗癌作用,2抗肝损害,3提高机体免疫功能。
葫芦素 E价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2025/02/05 | HY-N0417 | 葫芦素 E Cucurbitacin E | 18444-66-1 | 1 mg | 548元 |
2025/02/05 | HY-N0417 | 葫芦素 E Cucurbitacin E | 18444-66-1 | 5mg | 1200元 |
2025/02/05 | HY-N0417 | 葫芦素 E Cucurbitacin E | 18444-66-1 | 10mg | 1900元 |
常见问题列表
cyclin B1/CDC2
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Autophagy
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To explore the antitumor activity of Cucurbitacin E (CuE) against colorectal cancer (CRC) cells, an in vitro study is initiated in which each of the CRC cell lines is exposed to increasing doses of Cucurbitacin E (0, 2.5, 5, and 7.5 μM) over a period of 24 h. The proliferation of the Cucurbitacin E-treated cancer cells is then measured using the MTT method. Cucurbitacin E is shown to induce morphological changes in the primary colon cancer cells. Microscopic observation showed that following exposure to Cucurbitacin E (5 μM) between 6 and 24 h, the primary colon cancer cells underwent a remarkable change in morphology. Cucurbitacin E inhibits tumor growth by arresting the cell cycle in the G 2 /M phase via GADD45γ gene expression and the blockage of cyclin B1/CDC2 complex in primary CRC cells.
A high fat diet mice model of metabolic syndrome (HFD-MetS) is developed to assess the role of Cucurbitacin E (CuE) on body weight and fat tissue biology. Significant decrease in body weights of HFD-MetS mice treated with Cucurbitacin E (0.5mg/kg) are found as compared to HFD-MetS mice treated with vehicle alone. Cucurbitacin E treatment reduces all fat pads weights in HFD-MetS mice. 55% reduction is observed in total fat in mice, after treatment with Cucurbitacin E in comparison to HFD-MetS mice. Abdominal obesity is strongly associated with metabolic syndrome. Central obesity is reduced to 50% after Cucurbitacin E treatment as compared to HFD MetS mice, elucidating the effectiveness of Cucurbitacin E in targeting MetS.