180977-44-0
基本信息
GGTI-298
GGTI298 (GGTI-298
GGTI298 (CF3CO2H)salt
GGTI-298 trifluoroacetate salt
N-4-[2(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-NAPHTHYLBENZOYL-(L)-LEUCINE METHYL ESTER, TFA
L-Leucine, N-[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester
N-[[4-(2-(R)-AMINO-3-MERCAPTOPROPYL)AMINO]-2-NAPHTHYLBENZOYL]LEUCINE METHYL ESTER TRIFLUOROACETATE SALT
N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucinemethylestertrifluoroacetatesalt
N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt
物理化学性质
| 熔点 | 99.5-100 °C |
| 储存条件 | −20°C |
| 溶解度 | DMSO: 22 mg/mL |
| 形态 | solid |
| 颜色 | off-white |
GGTI-298价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-100876 | GGTI-298 GGTI298 | 180977-44-0 | 1mg | 900元 |
| 2024/11/08 | HY-100876 | GGTI-298 GGTI298 | 180977-44-0 | 5mg | 1800元 |
| 2024/11/08 | HY-100876 | GGTI-298 GGTI298 | 180977-44-0 | 10mg | 2800元 |
常见问题列表
IC50: 3 μM (Rap1A, in vivo), > 20 μM (Ha-Ras, in vivo)
Both RhoA inhibitor (GGTI298) and ROCK inhibitor (H1152) significantly reduce cAMP agonist-stimulated IK(ap), whereas the latter additionally reduces colocalization of KCNN4c with the apical membrane marker wheat germ agglutinin in T84WT cells. Knockdown of DR4 abolishes NF-κB activation, leading to sensitization of DR5-dependent apoptosis induced by the combination of GGTI298 and TRAIL. GGTI298/TRAIL activates NF-κB and inhibits Akt. knockdown of DR5, preventes GGTI298/TRAIL-induced IκBα and p-Akt reduction, suggesting that DR5 mediates reduction of IκBα and p-Akt induced by GGTI298/TRAIL. In contrast, DR4 knockdown further facilitates GGTI298/TRAIL-induced p-Akt reduction.
The vivo mouse ileal loop experiments show fluid accumulation is reduced in a dose-dependent manner by TRAM-34, GGTI298, or H1152 when injected together with cholera toxin into the loop.