供应商 相关产品 基本信息 理化性质 安全数据 4',6,7-三羟异黄酮价格(试剂级) 常见问题列表
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17817-31-1

供应商 相关产品 基本信息 理化性质 安全数据 4',6,7-三羟异黄酮价格(试剂级) 常见问题列表

产品图片

基本信息

英文
6,7,4'-Trihydroxyisoflavone
中文
4',6,7-三羟异黄酮
英文名称
4',6,7-TRIHYDROXYISOFLAVONE
6,7,4'-TRIHYDROXYISOFLAVONE
DEMETHYLTEXASIN
TRIHYDROXYISOFLAVONE, 4',6,7-
TRIHYDROXYISOFLAVONE, 4',6,7-(RG)
6,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
CAS
17817-31-1
中文名称
4',6',7'-三羟异黄酮
4',6,7-三羟基异黄酮
分子式
C15H10O5
MDL 编号
MFCD00016953
分子量
270.24
MOL 文件
17817-31-1.mol

理化性质

熔点 
>280℃
沸点 
587.1±50.0 °C(Predicted)
密度 
1.548±0.06 g/cm3(Predicted)
储存条件 
2-8°C
酸度系数(pKa)
6.85±0.20(Predicted)
CAS 数据库
17817-31-1(CAS DataBase Reference)

安全数据

安全说明 
S22-S24/25
WGK Germany 
3


10

4',6,7-三羟异黄酮价格(试剂级)

4',6,7-三羟异黄酮价格(试剂级)
更新日期产品编号产品名称CAS号包装价格
2022/10/21T34734',6,7-三羟基异黄酮
4',6,7-Trihydroxyisoflavone
17817-31-1200mg980元
2022/10/21T34734',6,7-三羟基异黄酮
4',6,7-Trihydroxyisoflavone
17817-31-11g3390元
2022/09/18HY-N50724',6,7-三羟异黄酮
Desmethylglycitein
17817-31-11mg2290元

常见问题列表

生物活性
Desmethylglycitein (4',6,7-Trihydroxyisoflavone),大豆苷元的代谢产物,来源于大豆 Glycine max,具有抗氧化性和抗癌活性。Desmethylglycitein 在体内直接结合 CDK1 和 CDK2,抑制 CDK1 和 CDK2 活性。Desmethylglycitein 是蛋白激酶 C (PKC)α 的直接抑制剂,抑制正常人皮肤成纤维细胞中的太阳紫外线 (sUV) 诱导的基质金属蛋白酶1 (MMP1)。Desmethylglycitein 以 ATP 竞争方式与细胞质中的 PI3K 结合,抑制 PI3K 和下游信号级联的活性,从而抑制 3T3-L1 前脂肪细胞中的脂肪形成。
靶点

CDK1

CDK2

PKC


体外研究

Desmethylglycitein (4',6,7-Trihydroxyisoflavone)(0-100 μM; 24-72 hours) suppesses anchorage-dependent growth of HCT-116 and DLD1 cells in a dose- and time-dependent manner without cytotoxicity . Desmethylglycitein (4',6,7-Trihydroxyisoflavone)(0-100 μM; 24-72 hours) suppresses CDK1 activity in a dose-dependent manner and inhibits CDK2 activity in HCT-116 cells. Desmethylglycitein (4',6,7-Trihydroxyisoflavone)(0-100 μM; 24-72 hours) induces cell cycle arrest at the S and G2/M phases, the percentage of cells in S phase is higher in the 100 μM 6,7,4′-THIF-treated group, and the same pattern is observed in G2/M phase (29.5% versus 19.1% ) .

Cell Viability Assay

Cell Line: HCT-116 cells
Concentration: 0, 12.5, 25, 50 or 100 μM
Incubation Time: 24, 48 or 72 hours
Result: Inhibited anchorage-dependent and -independent growth of HCT-116 cells.

Western Blot Analysis

Cell Line: HCT-116 and DLD1 cells
Concentration: 0, 25, 50 or 100 μM
Incubation Time: 48 hours
Result: Inhibited CDK1,CDK2 expression.

Cell Cycle Analysis

Cell Line: HCT-116 cells
Concentration: 0, 25, 50 or 100 μM
Incubation Time: 24, 48 or 72 hours
Result: Induces cell cycle arrest of HCT-116 cells at S and G2/M phases.

体内研究

Desmethylglycitein (4',6,7-Trihydroxyisoflavone) (intraperitoneally injection; 5 or 25 mg/kg; once daily; 20 days) suppresses tumor development in mice and serves as an effective anticancer treatment with the potential to inhibit or delay the tumorigenicity of HCT-116 cells in an in vivo system.

Animal Model: Female athymic nude mice subcutaneously injected with HCT-116 cells
Dosage: 5 or 25 mg/kg
Administration: Intraperitoneally injection; 5 or 25 mg/kg; once daily; 20 days
Result: Decreased tumor growth, volume and weight of HCT-116 xenografts.

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