146554-87-2

LY 290324 is an orally active, potent and selective cysteinyl leukotriene ((LTD4) receptor antagonist. In vitro, LY290324 was a potent and persistent antagonist of the contractile responses to LTD4 and LTE4 with pA2 values of 9.1 +/- 0.2 and 8.9 +/- 0.17 respectively. It is also effective in reducing antigen-induced bronchospasm in immunologically sensitised animals.

LY290324 是一种强效且具有口服活性的白三烯 D4 (leukotriene D4 (LTD4)) 拮抗剂。LY290324 可减轻 LTC4、LTD4 和 LTE4 (HY-113465) 诱发的支气管痉挛。LY290324 具有研究抗原诱发的支气管痉挛的潜力。