136831-48-6
基本信息
酪氨酸磷酸化抑制剂RG 13022
TYROSINE KINASE抑制剂(RG13022)
3-(3,4-二甲氧基苯基)-2-(吡啶-3-基)丙烯腈
RG13022, >98%
RG13022
RG 13022
TYRPHOSTIN RG 13022
α-(3-Pyridyl)-3,4-dimethoxybenzeneacrylonitrile
ALPHA-(3'-PYRIDYL)-(3,4-DIMETHOXY)CINNAMONITRILE
3-(3,4-Dimethoxyphenyl)-2-(3-pyridinyl)propenenitrile
3-(3,4-dimethoxyphenyl)-2-(pyridin-3-yl)acrylonitrile
2-(3,4'-DIMETHOXYPHENYL)-1-(3''-PYRIDINYL)ACRYLONITRILE
3-Pyridineacetonitrile,a-[(3,4-dimethoxyphenyl)methylene]-
物理化学性质
| 熔点 | 116.0 to 120.0 °C |
| 储存条件 | −20°C |
| 溶解度 | DMSO or ethanol: soluble |
| 形态 | 白色固体。 |
| 颜色 | 白色到黄色到绿色 |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H315-H319-H335 |
| 防范说明 | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| 安全说明 | 22-24/25 |
| WGK Germany | 3 |
| 海关编码 | 2933.39.9200 |
RG-13022价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-101429 | RG-13022 RG13022 | 136831-48-6 | 2mg | 400元 |
| 2024/11/08 | HY-101429 | RG-13022 RG13022 | 136831-48-6 | 5mg | 560元 |
| 2024/11/08 | HY-101429 | RG-13022 RG13022 | 136831-48-6 | 10mM * 1mLin DMSO | 586元 |
常见问题列表
| Target | Value |
|
EGFR
(Cell-free assay) | 4 μM |
RG13022 suppresses EGF-stimulated cancer cell proliferation. In a cell-free reaction RG13022 inhibits the autophosphorylation reaction of the EGF receptor in immunoprecipitates with an IC 50 of 4 μM. RG13022 inhibits colony formation and DNA synthesis by HER 14 cells, which were stimulated by 50 ng/mL EGF, in a dose-dependent manner. The IC 50 s are 1 and 3 μM for HER 14 colony formation and DNA synthesis, respectively. RG-13022 inhibits not only EGF-induced growth but also growth stimulated by insulin, insulin-like growth factor I, insulin-like growth factor II, or transforming growth factor alpha. RG-13022 also totally blocks estrogen-stimulated phosphorylation of the EGF receptor, as well as estrogen-induced cell proliferation, suggesting that functioning TK pathways are required for estrogen action.
RG13022 suppresses tumor growth in nude mice. RG13022 also increases the life span of these tumor-bearing nude mice.