1338247-30-5
基本信息
BMS-3 ≥95%
BMS3
BMS 3
BMS-3
BMS-3 >=95% (HPLC)
N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)cyclopropanecarboxaMide
N-[5-[2-(2,6-dichlorophenyl)-5-(difluoromethyl)pyrazol-3-yl]-1,3-thiazol-2-yl]cyclopropanecarboxamide
N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-cyclopropanecarboxamide
Cyclopropanecarboxamide, N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-
物理化学性质
密度 | 1.69±0.1 g/cm3(Predicted) |
储存条件 | Sealed in dry,Store in freezer, under -20°C |
溶解度 | DMF: 15 mg/ml; DMSO: 25mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.2 mg/ml; Ethanol: 1 mg/ml |
酸度系数(pKa) | 8.28±0.70(Predicted) |
形态 | 结晶固体 |
颜色 | White to off-white |
安全数据
危险性符号(GHS) | GHS07,GHS02 |
警示词 | 警告 |
危险性描述 | H315-H319-H226 |
防范说明 | P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235 |
BMS-3价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2023/01/06 | S3525 | BMS-3 BMS-3 | 1338247-30-5 | 25mg | 5872.98元 |
2021/03/30 | S3525 | BMS-3 BMS-3 | 1338247-30-5 | 5mg | 1957.98元 |
常见问题列表
LIMK1 5 nM (IC 50 ) |
LIMK2 6 nM (IC 50 ) |
BMS-3 (Compound 2) causes a dose-dependent reduction in cell count and induces mitotic arrest by increases in total nuclear DNA intensity and histone H3 phosphorylation after 24 h treatment in A549 human lung cancer cells. BMS-3 inhibits A549 human lung cancer cells with EC 50 value of 154 nM. BMS-3 is used to demonstrate the direct participation of LIMK1 in the phosphorylation of Cofilin. Inhibition of p-LIMK with 1-50 μM of BMS-3 results in a dose-dependent decrease of p-Cofilin after 10 min incubation in capacitating conditions. As a control, sperm are also incubated for 10 min under non-capacitating conditions which result in low levels of p-Cofilin. In the presence of 1 or 50 μM of BMS-3, actin polymerization levels are significantly lower compared to controls (DMSO). Mouse sperm are incubated under capacitating conditions for 90 min in the presence or absence of increasing concentrations of p-LIMK inhibitor BMS-3 (0, 1, 10 and 50 μM). The increasing concentrations of BMS-3 result in a strong decrease on the percentage of sperm that undergoes acrosomal exocytosis after stimulation with 20 μM of Progesterone.