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Enarodustat, also known as JTZ-951, is a prolyl hydroxylase inhibitor. JTZ-951 (enarodustat) stabilizes HIF-α protein and induces erythropoiesis without effects on the function of vascular endothelial growth factor. Enarodustat increases endogenous erythropoietin levels in the treatment of anemia associated with chronic kidney disease (CKD). JTZ-951 induces erythropoiesis without affecting VEGF function. JTZ-951 may be a new oral candidate that increases and maintains hemoglobin concentrations in renal anemia patients.

Enarodustat hydrochloride 是一种有效的，可口服的 HIF/HIF Prolyl-Hydroxylase 抑制剂，EC50 of 0.22 μM。Enarodustat hydrochloride 有潜力用于肾性贫血症的研究。

恩那度司他是一种口服活性HIF-PH抑制剂，可通过促进促红细胞生成素的内源性生产并控制负责铁代谢的分子的表达来促进促红细胞生成。

恩那度司他是一种贫血口服新药，可用于治疗与慢性肾脏病(CKD)相关的贫血。