1222102-29-5

Developed by Dong-A ST, evogliptin was approved in 2015 in the Republic of Korea for blood glucose control in patients with diabetes mellitus type 2 (type 2 DM). Evogliptin is an orally bioavailable dipeptidyl peptidase IV (DPP-4) inhibitor, which acts to prevent insulin secretion following meals. Dong-A ST arranged licensing agreements with Geropharm and Eurofarma Laboratórios for the sale of evogliptin in various countries in eastern Europe and Brazil, respectively, pending future approvals. While a manufacturing route has not been disclosed to date, the most scalable published route is described below.