1135-23-5
基本信息
3-(4-羟基甲基)丙酸
氢化阿魏酸
3-(4-羟基-3-甲氧基苯基)丙酸
3-(4-HYDROXY-3-METHOXYPHENYL)PROPANOIC ACID
3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID
3-(4-HYDROXYMETHYL)PROPIONIC ACID
3-METHOXY-4-HYDROXYHYDROCINNAMIC ACID
4-HYDROXY-3-METHOXYHYDROCINNAMIC ACID
BETA-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID
HYDROFERULIC ACID
Benzenepropanoic acid, 4-hydroxy-3-methoxy-
3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC
HYDROFERULIC ACID(RG)
3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID 98%
3-Methoxy-4-hydroxybenzenepropanoic acid
3-Methoxy-4-hydroxybenzenepropionic acid
4-Hydroxy-3-methoxybenzenepropanoic acid
物理化学性质
| 熔点 | 87-93 °C |
| 沸点 | 120-130 °C(Press: 0.5 Torr) |
| 密度 | 1.259±0.06 g/cm3(Predicted) |
| 储存条件 | Storage temp. 2-8°C |
| 溶解度 | 溶于二甲基亚砜和甲醇。 |
| 酸度系数(pKa) | 4.73±0.10(Predicted) |
| 形态 | 粉末晶体 |
| 颜色 | 白色至浅黄色 |
| BRN | 2110370 |
| InChI | InChI=1S/C10H12O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2,4,6,11H,3,5H2,1H3,(H,12,13) |
| InChIKey | BOLQJTPHPSDZHR-UHFFFAOYSA-N |
| SMILES | C1(CCC(O)=O)=CC=C(O)C(OC)=C1 |
| LogP | 0.810 (est) |
| CAS 数据库 | 1135-23-5(CAS DataBase Reference) |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H315-H319-H335 |
| 防范说明 | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
| 危险品标志 | Xn |
| 危险类别码 | R22-R36/37/38 |
| 安全说明 | S26-S36 |
| WGK Germany | 2 |
| 危险等级 | IRRITANT |
| 海关编码 | 29189900 |
| 存储类别 | 11 - Combustible Solids |
| 危险性类别 | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
制备方法
1135-24-6
1135-23-5
以3-甲氧基-4-羟基苯基丙烯酸为原料合成磷酸异丙酯(单双酯混合物)的一般步骤如下：向搅拌的阿魏酸（25g，128.74mmol）在甲醇（200ml）中的悬浮液中加入Pd/C催化剂（3.75g）。将反应混合物置于1.2MPa氢气压力下，在50℃条件下氢化4小时。反应完成后，将混合物冷却至室温，过滤去除催化剂，并通过减压浓缩得到白色固体产物（25g，收率99%）。产物的结构通过1H NMR（400MHz，CDCl3）和ESI-MS进行确认：1H NMR δ 6.76（d, J = 7.8Hz, 1H），6.62（m, 2H），3.79（s, 3H），2.81（t, J = 7.7Hz, 2H），2.58（t, J = 7.7Hz, 2H）；ESI-MS m/z: 195.1 [M-H]?。
参考文献：
[1] Advanced Synthesis and Catalysis, 2013, vol. 355, # 1, p. 81 - 86
[2] Tetrahedron Letters, 2010, vol. 51, # 44, p. 5753 - 5756
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 13, p. 4462 - 4466
[4] European Journal of Medicinal Chemistry, 2014, vol. 87, p. 429 - 439
[5] Journal of the American Chemical Society, 2017, vol. 139, # 10, p. 3767 - 3773
图谱信息
磷酸异丙酯(单双酯混合物)(1135-23-5)质谱(MS)磷酸异丙酯(单双酯混合物)(1135-23-5)核磁图(1HNMR)磷酸异丙酯(单双酯混合物)(1135-23-5)核磁图(13CNMR)磷酸异丙酯(单双酯混合物)(1135-23-5)红外图谱(IR1)磷酸异丙酯(单双酯混合物)(1135-23-5)红外图谱(IR2)知名试剂公司产品信息
磷酸异丙酯(单双酯混合物)价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/07/06 | A12069 | 3-(4-羟基-3-甲氧基苯基)丙酸, 97% 3-(4-Hydroxy-3-methoxyphenyl)propionic acid, 97% | 1135-23-5 | 5g | 2302元 |
| 2026/07/06 | S5135 | 磷酸异丙酯(单双酯混合物) Hydroferulic acid | 1135-23-5 | 25mg | 794.8元 |
| 2026/06/06 | H1180 | 3-(4-羟基-3-甲氧苯基)丙酸 3-(4-Hydroxy-3-methoxyphenyl)propionic Acid | 1135-23-5 | 1G | 350元 |
常见问题列表
Uptake of hydroxycinnamic acids by control, organic anion transporter 1 (OAT1), OAT2, OAT3, and OAT4 over expressing 293H cells. In 293H control cells, there was significant uptake of Dihydroferulic acid. The uptake of Dihydroferulic acid is also enhanced ~2-fold in the OAT1-expressing cells.
Assessing the influence of an 11 weeks intervention with a resistant starch-enriched whole grain diet (HI-RS-WG, 25% RS) compared to a WG control diet (LOW-RS-WG, 6.9% RS) on serum profile of polyphenols (PPs) in 20 Zucker Diabetic Fatty rats. Five PPs were identified and quantified in serum samples of rats belonging to both intervention groups. HI-RS-WG rats had 2.6 folds higher serum concentrations of total PPs than LOW-RS-WG rats. An explorative data reduction approach, based on the Principal Component Analysis identified two principal components related to the gut microbiota fermentation and food intake, respectively. Results showed that the abundance of hippuric acid and Dihydroferulic acid in HI-RS-WG rats was explained by the stronger gut microbiota fermentation in those rats than in LOW-RS-WG rats.