961-07-9

Crystalline

Nucleoside analog

ChEBI: A purine 2'-deoxyribonucleoside having guanine as the nucleobase.

8-Hydroxy-2'-deoxyguanosine (8-OHdG) is the most commonly used marker of DNA oxidation for the diagnosis of oxidative DNA damage and bipolar disorder (BD), as well as for the prevention of plaque formation and for the inhibition of vascular smooth muscle cell activation through Rac1 inactivation.

2‘-Deoxyguanosine (2’dGuo) is a purine nucleoside metabolite that has been shown to inhibit proliferation-dependent antigen-specific suppressor T cell (Ts) function in mouse and human systems. 2'dGuo also inhibits mitogen-induced T cell proliferation. Low concentrations (40 gM) of 2'dGuo enhanced phytohemagglutinin- and amantadine A-induced T-cell transformation, possibly due to the inhibition of T-cell function leading to the promotion of T-cell growth factor production. T-cell responses were inhibited only when the concentration of 2'dGuo was toxic to lymphocytes.^[1]

Human Endogenous Metabolite

Store at -20°C

2'-Deoxyguanosine recrystallises from H2O as the monohydrate. [Brown &C5440 Lythgoe J Chem Soc 1990 1950, L

[1] A C HANGLOW; P M L. The effect of 2’deoxyguanosine on human lymphocyte responses. I. 2’deoxyguanosine enhances T lymphocyte responses.[J]. Clinical and experimental immunology, 1985, 59 3: 653-658.