96-20-8

2835-81-6

96-20-8

22621-37-0

The general procedure for the synthesis of 2-amino-1-butanol and compounds (CAS:22621-37-0) from DL-2-aminobutyric acid is as follows: Preparation of (+) - 2-amino-1-butanol (Example 9): 1. 1.8 g of L-2-aminobutyric acid obtained in Example 5 was dispersed in 30 mL of ethanol. 2. Dry hydrogen chloride gas was passed into this dispersed system until the L-2-aminobutyric acid was completely dissolved to form a homogeneous solution. 3. The resulting solution was refluxed for 4 hours. 4. Upon completion of the reaction, the reaction mixture was cooled and the ethanol was subsequently evaporated under reduced pressure. 5. The residue was dissolved in cooled ammonia and subsequently extracted with ether. 6. 6. The ether extracts were combined and dried with magnesium sulfate. 7. After drying, distillation was carried out under reduced pressure to collect the fraction with a boiling point of 66°C-67°C/18 mmHg to give 2.0 g of ethyl L-2-aminobutyrate in 90% yield. 8. The product had a specific optical rotation of 0.01%. 8. The specific optical rotation of the product was (α)D27 = +17.8°±1° (C=5.6, ethanol).