935-95-5

Leaflets (from ligroin) or light beige powder.

2,3,5,6-TETRACHLOROPHENOL(935-95-5) is incompatible with acid chlorides, acid anhydrides and oxidizing agents. .

Insoluble in water.

Flash point data for this chemical are not available. 2,3,5,6-TETRACHLOROPHENOL is probably combustible.

Brown solid; phenol odor. Soluble in sodium hydroxide solutions and most organic solvents; insoluble in water.

ChEBI: The 2,3,5,6-isomer of tetrachlorophenol

Chlorophenols are generally prepared by the chlorination of phenol. There are other routes of synthesis as through diazotizing p-chloroaniline or dechlorinating (by alkaline hydrolysis) 1,2,4,5-tetrachlorobenzene to yield 2,4,5-trichlorophenol (TCP). Polychlorinated dibenzo-p-dioxins can be formedduringthemanufacturingprocess of the chlorophenols. The amount formed depends on temperature and pressure process variability during production. The more notable toxic dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD), is formed during the production of 2,4,5- TCP. Laboratory reference standards of 2,3,7,8-TCDD are prepared by heating 2,4,5-TCP under alkaline conditions. All technical and formulated products containing 2,4,5-TCP are expected to be contaminated to varying degrees by this 2,3,7,8-TCDD by-product of the manufacturing process.

Toxic by ingestion and inhalation, strong irritant.

There was no evidence of carcinogenic activity of 2,4-dichlorophenol in F344/N rats or B6C3F1 mice from the NTP bioassay program, but 2,4,6-trichlorophenol was reported to be carcinogenic in both species.

Crystallise the phenol from pet ethers. The benzoate has m 136o (from EtOH). [Beilstein 6 II 182, 6 III 730, 6 IV 1025.]