914088-64-5

Name	Cazpaullone
CAS	914088-64-5
Molecular Formula	C16H10N4O
MDL Number	MFCD18782605
Molecular Weight	274.28
MOL File	914088-64-5.mol

Synonyms

Cazpaullone MGQSIUXWCFOENX-UHFFFAOYSA-N Cazpaullone (9-Cyano-1-azapaullone)

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Chemical Properties

Boiling point	680.7±50.0 °C(Predicted)
density	1.49±0.1 g/cm3(Predicted)
pka	13.34±0.20(Predicted)

Hazard Information

Description

Cazpaullone is a glycogen synthase kinase-3 (GSK-3) inhibitor. Cazpaullone shows transient stimulation of the mRNA expression of the beta cell transcription factor Pax4, an important regulator of beta cell development and growth. Cazpaullone has potential as a starting point for developing agents for the treatment of diabetes.

Uses

Cazpaullone is a glycogen synthase kinase-3 (GSK-3) inhibitor. Cazpaullone can activate pancreatic beta cell protection and replication. Cazpaullone can be used for the research of diabetes[1].

References

[1] Stukenbrock H, et al. 9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication. J Med Chem. 2008 Apr 10;51(7):2196-207. DOI:10.1021/jm701582f

Supplier

Foshan Heshuo Pharm technology Co., ltd

Telephone 15363639686

Websitehttp://www.hs-pharm.cn

Nanjing Shizhou Biology Technology Co.,Ltd

Telephone025-85560043 15850508050

Websitehttp://www.synzest.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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