910209-21-1

Sodium Cyclopropanesulfinate is a general chemical reagent used in the synthesis of AMG 232 (A576560), a potent MDM2-P53 inhibitor for use as an anti-tumor agent.

Sodium cyclopropyl sulfite was prepared as follows: sodium sulfite (1.32 g, 1.1 mmol), sodium bicarbonate (1.6 g, 20.0 mmol) was dissolved in pure water (15 mL), and the reaction was stirred at 55 ° C for 10 min, then cyclopropylsulfonyl chloride (1.4 g,