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91-21-4

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Identification

Name
1,2,3,4-TETRAHYDROISOQUINOLINE
CAS
91-21-4
Synonyms
1,2,3,4-TETRAHYDROISOQUINOLINE
AKOS BB-9293
LABOTEST-BB LTBB000776
1,2,3,4-Tetrahydro-2-azanaphthalene
1,2,3,4-Tetrahydro-2-isoquinoline
1,2,3,4-tetrahydro-isoquinolin
Tetrahydroisoquinoline
1,2,3,4-Tetrahydro-#niso-quinoline
3,4-Dihydro-1H-isoquinoline.
1,2,3,4-Tetrahydroisoquinoline ,97%
EINECS(EC#)
202-050-0
Molecular Formula
C9H11N
MDL Number
MFCD00006896
Molecular Weight
133.19
MOL File
91-21-4.mol

Chemical Properties

Appearance
clear yellow to brown liquid
mp 
−30 °C(lit.)

bp 
232-233 °C(lit.)

density 
1.064 g/mL at 25 °C(lit.)

refractive index 
n20/D 1.568(lit.)

Fp 
210 °F

BRN 
116156
CAS DataBase Reference
91-21-4(CAS DataBase Reference)

Safety Data

Hazard Codes 
Xi
Risk Statements 
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
WGK Germany 
3

RTECS 
NX4900000

Hazard Note 
Irritant
HS Code 
29334900

Raw materials And Preparation Products

Questions And Answer

Description
1, 2, 3, 4-TETRAHYDROISOQUINOLINE belongs to tetrahydroisoquinoline compound, which is encountered in a number of drugs, tubocurarine, one of the quaternary ammonium muscle relaxants1-3. It is used as a reagent in the preparation of4-(1, 2, 4-oxadiazol-5-yl) piperidine-1-carboxamides as antiproliferative tubulin inhibitors1. It can be used for the synthesis of 1, 2, 3, 4-tetrahydroisoquinoline-3-carboxylic acid (Tic), which has strong applications in peptides and peptidomimetics design and discovery2. 1, 2, 3, 4-tetrahydroisoquinoline has been made into some derivatives with potential for prevention of parkinsonism4, cancer treatment5 and acting as Anticonvulsant Agents6.
Reference
  1. https://www.alfa.com/en/catalog/L08143/
  2. https://www.ncbi.nlm.nih.gov/pubmed/21235510
  3. https://en.wikipedia.org/wiki/Tetrahydroisoquinoline
  4. Okuda, K, Y. Kotake, and S. Ohta. "Parkinsonism-preventing activity of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline derivatives in C57BL mouse in vivo. Biological & Pharmaceutical Bulletin 29.7(2006):1401-1403.
  5. Luca, Laura De, et al. "3D Pharmacophore Models for 1, 2, 3, 4‐Tetrahydroisoquinoline Derivatives Acting as Anticonvulsant Agents." Archiv Der Pharmazie 339.7(2006):388-400.
  6. Hatano, H, et al. "Tumor-specific cytotoxic activity of 1, 2, 3, 4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines."Anticancer Research 29.8(2009):3079-3086.

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