Succinyl-CoA synthetase catalyzes the only substrate-level phosphoryl-ation step in the tricarboxylic acid cycle. Succinyl-CoA synthetase is a phosphate target for the activation of mitochondrial metabolism[1][2].
References
[1] Huang J, et al. Tartryl-CoA inhibits succinyl-CoA synthetase. Acta Crystallogr F Struct Biol Commun. 2020 Jul 1;76(Pt 7):302-308. DOI:10.1107/S2053230X20008201 [2] Phillips D, et al. Succinyl-CoA synthetase is a phosphate target for the activation of mitochondrial metabolism. Biochemistry. 2009 Aug 4;48(30):7140-9. DOI:10.1021/bi900725c
