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Material Safety Data Sheet(MSDS)

Questions And Answer

• Product features

  Hydroxypropyl methyl cellulose is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.It is white or pale white cellulose powder or particles. The characteristics of cold water dissolution and hot water insoluble are similar with methyl cellulose. Solubility in organic solvents is superior than water soluble, can be dissolved in anhydrous methanol and ethanol solution, also soluble in chlorinated hydrocarbons and ketones in organic solvents. Soluble in water, its water solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the reversible conversion of sol to gel. Can be used alone in the cold drink, also can be used with other emulsifier, stabilizer. To cold drink, the maximum amount is 1%. Hydroxypropyl methyl cellulose and other water-soluble high weight compounds use mixture, become transparent, higher viscosity. The gelation temperature of low viscosity products is higher than high viscosity of products. Its solution is stable at room temperature. In recent years, It has been widely used in petroleum chemical industry, papermaking, leather, textile printing and dyeing, pharmaceutical, food, cosmetics and other industries, and as the dispersing agent, thickening agent, adhesive, excipient, capsule, oil resistant coating and packing etc.
  
  Figure 1 The molecular structure of hydroxypropyl methyl cellulose ;

• Chemical Properties

  Hydroxypropyl methyl cellulose is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.It is white or pale white cellulose powder or particles.It has different types of products, the methoxy and hydroxypropyl content ratio is different. It is white or gray fibrous powder or particles. It is soluble in water and some organic solvents and unsoluble in ethanol. Aqueous solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the sol to gel reversible transformation.;

• Applications

  Hydroxypropyl Methyl Cellulose (HPMC) are water soluble polymers derived from cellulose. They are typically used as thickeners, binders, film formers, and water retention agents. They also function as suspension aids, surfactants, lubricants, protective colloids, and emulsifiers. In addition, solutions of these polymers thermally gel.
  hydroxypropyl methyl cellulose has many excellent properties. lt is presented below some examples of HPMC applications:
  Food industry: stabilizers of emulsions and foams, as a replacement for fat, as a non-caloric bulking agentin foods, as a binder, among others.
  Pharmaceutical industry: as a dispersing and thickening agent, film-coating of tablets, drug preparations,among others.
  Cosmetics industry: hair shampoo, eye makeup, skin care preparations, among others. ;

• Liquid Detergents

  Hydroxypropyl methyl cellulose and methyl cellulose are also water-soluble nonionic polymers. They are compatible with inorganic salts and ionic species up to a certain concentration. Methyl cellulose can be salted out of solution when the concentration of electrolytes or other dissolved materials exceeds certain limits. Hydroxypropyl methyl cellulose has a higher tolerance for salts in solution than methyl cellulose. Both are stable over a pH range of 3 to 11. Commercial water-soluble methyl cellulose products have a methoxy DS of 1.64 to 1.92. A DS of lower than 1.64 yields material with lower water solubility.The methoxy DS in hydroxypropyl methyl cellulose ranges from 1.3 to 2. Thehydroxypropyl MS ranges from 0.13 to 0.82. Methyl cellulose and hydroxypropyl methyl cellulose polymers have a number of applications and are used as thickeners in latex paints,food products,shampoos,creams and lotions, and cleansing gels. U.S.Patent 5,565,421 is an example of the use of hydroxypropylmethyl cellulose polymer to gel a light-duty liquid detergent containing anionic surfactants.;

• Identification test

  It is soluble in water swelling, forming a transparent milky white sticky gel solution, and insoluble in ethanol. ;

• Toxicity

  ADI does not make special provisions (FAO/WHO, 2001). It can be used for food safety (FDA. §172.87, 2000). LD505200mg/kg (rats, intra peritoneal injection). ;

• Limited use

  FAO/WHO (1984): Cold drink ,10g/kg (in the end product design, single use or with other emulsifier, stabilizer and thickener dosage).
  GB 2760-96: all kinds of food, to GMP limited. ;

• Methods of production

  Hydroxypropyl methyl cellulose is obtained by treatment of fibrous plant material with alkali, methyl chloride and propylene oxide.
  1.The refined cotton cellulose with alkali treatment at 35-40 ℃ for half an hour, press, crushed the cellulose, aging at 35 ℃, so that the average degree of polymerization of alkali cellulose is in a desired range. The alkali fiber into etherification reactor, followed by adding epoxy propane and methane chloride, etherification at 50-80 ℃ for 5h, the maximum pressure is about 1.8MPa. The reaction products were produced by postprocessing (hydrochloric acid and oxalic acid, washing and drying). The consumption of raw material of cotton pulp 1100kg/t, methyl chloride and propylene oxide 4300kg/t, solid alkali 1200kg/t, hydrochloride 30kg/t, oxalic acid 50kg/t.
  2.100 kg refined cotton linters immersed in 45% solution, temperature is 35 to 40℃, time is 0.5 to 1 h, and then remove the press. The pressure to weight is 2.7 times as the weight of lint, stop pressure. Carry out the crushing. At 35℃, aging for 16h.
  In the reaction kettle, the chlorinated methane, propylene oxide were added into the reaction kettle. At 80℃, the pressure was 1.8 MPa, the reaction time is 5 to 8 h, and the amount of hydrochloric acid and oxalic acid were added to the hot water at 90℃. Dewatering with centrifuge, washing to neutral, when the water content of the material is below to 60% , 130℃ of hot air flow dried to the moisture content is below 5%. Finally, the finished product sieved by 20 mesh.
  3. Prepared by cellulose, methyl chloride, and ethylene oxide.;

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