ChemicalBook CAS DataBase List 9004-06-2

9004-06-2

Name	Elastase
CAS	9004-06-2
EINECS(EC#)	232-670-7
MDL Number	MFCD00130997

Chemical Properties

storage temp.	−20°C
form	lyophilized powder
color	White to off-white
biological source	rabbit
Specific Activity	≥50units/mg protein (Bradford)
CAS DataBase Reference	9004-06-2
EPA Substance Registry System	Elastase(9004-06-2)

Safety Data

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H315-H319-H334-H335
Precautionary statements	P261-P264-P271-P302+P352-P304+P340+P312-P305+P351+P338
Hazard Codes	B
WGK Germany	3
F	3-10
TSCA	TSCA listed
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Resp. Sens. 1 Skin Irrit. 2 STOT SE 3

Raw materials And Preparation Products

Hazard Information

Chemical Properties

Elastase is a white or light gray crystalline powder. It is soluble in water and stable at pH 4-10.5 and 20°C. Stability is extended at pH 6<10.5. Its isoelectric point is pH 9.5. It is hygroscopic. The lyophilized powder can be stored at 50°C for 3-12 months. Compound elastase ointment is a white ointment containing elastase and neomycin sulfate.

Uses

Elastase from human leukocytes has been used:

to measure serum elastase activity
in proteolytic digestion of fibronectin and salivary glands
in neutrophil elastase (NE) activity assay
cell-free NE digestion of E-cadherin
scratch wound assay
in a study that determined that fragments of Nle3-angiotensin(1-7) accelerate healing in dermal models

Elastase has been used to digest fibronectin. The results were compared with fibronectin digestion by crude human leukocyte homogenate to examine the presence of fibronectin peptides in saliva of patients with Sj?gren′s syndrome. It has also been used as a reference to determine the elastase activity in cell lysates. This study examined the effect of all-trans retinoic acid on procoagulant and fibrinolytic activities of cultured blast cells. These blast cells were from patients with acute promyelocytic leukemia.

General Description

Elastase is a proteolytic enzyme. It is a member of the subgroup named, peptidyl peptide hydrolases. It is a major anatomic constituent of arteries. It is mainly found in the pancreas and pancreatic juice of various birds and mammals. It is also present in human serum, granulocytes and erythrocytes.

Biochem/physiol Actions

Elastase enzyme is capable of releasing soluble peptides from insoluble elastin fibers with the help of a proteolytic process. It can stimulate disintegration of the axoneme with the help of adenosine triphosphate (ATP). Unlike pancreatic elastase the leukocyte enzyme has a preferential cleavage for the carboxyl side of valine, but will also cleave to a lesser extent after alanine. Natural substrates include elastin, cartilage proteoglycans, collagen types I, II, II and IV, and fibronectin.

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