89446-19-5

(b) N-(4-bromophenyl)-3-oxobutanamide (0.73 g, 2.85 mmol) was dissolved in concentrated hydrochloric acid. The reaction was heated to 120 °C in an oil bath and sodium sulfate (7 mL) was added and kept at this temperature for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into a beaker containing ice. The precipitate precipitated was collected by filtration to afford 6-bromo-4-methyl-2(1H)-quinolinone as a tan solid (0.4 g, 60% yield).

[1] Patent: WO2010/132615, 2010, A1. Location in patent: Page/Page column 138
[2] Synthesis, 2011, # 6, p. 934 - 942
[3] Patent: US2005/234101, 2005, A1. Location in patent: Page/Page column 14
[4] Patent: WO2005/103002, 2005, A2. Location in patent: Page/Page column 44
[5] Patent: US2005/267115, 2005, A1. Location in patent: Page/Page column 21