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290-37-9

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Identification

Name
Pyrazine
CAS
290-37-9
Synonyms
1,4-DIAZINE
FEMA 4015
FEMA NUMBER 4015
PYRAZINE
PYRAZINE MIXTURE
1,4-Diazabenzene
Paradiazine
p-Diazine
Piazine
Pyrazin
zhejiangjianfengpharmaceuticalholdingspyrazine
PYRAZINE 99+%
1,4-Pyrazine
ACETYL PYRAZINE, 2-(SG)
PYRAZINE(SG)
EINECS(EC#)
206-027-6
Molecular Formula
C4H4N2
MDL Number
MFCD00006122
Molecular Weight
80.09
MOL File
290-37-9.mol

Chemical Properties

Appearance
white crystals or powder
Melting point 
50-56 °C (lit.)
mp 
50-56 °C(lit.)

Boiling point 
115-116 °C (lit.)
bp 
115-116 °C(lit.)

density 
1.031 g/mL at 25 °C(lit.)

refractive index 
1.5235
FEMA 
4015
Fp 
132 °F

storage temp. 
Flammables area
solubility 
SOLUBLE
form 
Crystals
pka
0.65(at 27℃)
Specific Gravity
1.031
color 
White
Stability:
Stable. Highly flammable. Incompatible with acids, oxidizing agents.
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
Merck 
14,7957
Detection Methods
GC,NMR
JECFA Number
951
BRN 
103905
CAS DataBase Reference
290-37-9(CAS DataBase Reference)
NIST Chemistry Reference
Pyrazine(290-37-9)
EPA Substance Registry System
290-37-9(EPA Substance)

Safety Data

Hazard Codes 
Xi,F
Risk Statements 
R36/37/38:Irritating to eyes, respiratory system and skin .
R11:Highly Flammable.
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S16:Keep away from sources of ignition-No smoking .
RIDADR 
UN 1325 4.1/PG 2

WGK Germany 
3

RTECS 
UQ2015000

TSCA 
T
HazardClass 
4.1
PackingGroup 
III
HS Code 
29339990

Raw materials And Preparation Products

Material Safety Data Sheet(MSDS)

msds information
1,4-Diazine(290-37-9).msds

Questions And Answer

Description
Pyrazine is a heterocyclic aromatic organic compound and can be reacted to obtain diverse pyrazine derivatives. Pyrazines are important contributors to the flavor of various roasted, toasted, or similarly heated foods. Pyrazine derivatives exhibit a wide variety of aromas in food, e.g. 2-methoxy-3-isopropylpyrazine produces a green pea odor. Pyrazines and pyrazine derivatives are typically used as flavor agent. Pyrazines and Pyrazine derivatives are also used as fragrances.
References
[1] T.B. Adamsa, J. Doullb, V.J. Feronc, J.I. Goodmand, L.J. Marnette, I.C. Munrof, P.M. Newberneg, P.S. Portogheseh, R.L. Smithi, W.J. Waddellj and B.M. Wagnerk, The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients, Food and Chemical Toxicology, 2002, vol. 40, 429-451

Hazard Information

Chemical Properties
Pyrazine has a strong pyridine-like odor. Some reports compare the taste of pyrazine to cooked spinach or rancid peanuts
Chemical Properties
white crystals or powder
Occurrence
Pyrazine has been detected in several food products including papayas, asparagus, peanuts, popcorn, soybeans, corn, French fries, bread, cheese, milk, eggs (boiled), chicken (fried), beef (cooked), shrimp, clams, beer, sherry, malt, coffee and tea (green).
Uses
Pyrazine is used as a flavoring agent. It serves as a component of some herbs in traditional Chinese medicine. It is employed as pharmaceutical intermediates, perfume intermediates and involved in the preparation of other chemicals. In addition to this, it is used in the production of pyrazine 1-oxide.
Definition
pyrazine: An unsaturated heterocycliccompound having two nitrogenatoms in a six-membered ring,C4H4N2; r.d. 1.03; m.p. 52°C; b.p.115°C. Pyrazine is a symmetric diazine.
Definition
A heterocyclic aromatic compound with a six-membered ring containing four carbon atoms and two nitrogen atoms.
Definition
ChEBI: A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.
Preparation
Prepared by cyclization of α-amino ketones, which were produced by the reduction of isonitroso ketones to yield the dihydropyrazines, which are dehydrogenated with mercury(I) oxide or copper(II) sulfate or sometimes with atmospheric oxygen.
Aroma threshold values
300 ppm (odor threshold in water)
General Description
Pyrazine is a 1,4-diazine and an electron-deficient N-heteroarene found in several natural products, APIs, agrochemicals, and functional materials.

Purification Methods
Distil pyrazine in steam and crystallise it from water. Purify also by zone melting. [Beilstein 23 H 91, 23 II 80, 23 III/IV 899, 23/5 V 351.]

Spectrum Detail

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