893421-54-0

Imidafenacin hydrochloride is a potent and selective inhibitor of M3 receptors with a Kb of 0.317 nM[1].

Imidafenacin exhibits anticholinergic properties. It also has potential therapeutic effects on prostatic hyperplasia.''Imidafenacin is a potent antimuscarinic agent th at exhibits selectivity toward muscarinic M3 receptors with Kb of 0.317 nM. Imidafenacin is used for treating overactive bladder.

[1] Miyachi H, et al. Synthesis and antimuscarinic activity of a series of 4-(1-Imidazolyl)-2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents. Bioorg Med Chem. 1999 Jun;7(6):1151-61. DOI:10.1016/s0968-0896(99)00003-6
[2] Yamazaki T, et al. Imidafenacin has no influence on learning in nucleus basalis of Meynert-lesioned rats. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1095-102. DOI:10.1007/s00210-013-0910-z