1977-07-7

Deschloroclozapine has greater potencies for DREADDs than previous agonists in vitro. Deschloroclozapine is a potent agonist for hM ₃ Dq with an EC ₅₀ =0.13 nM. Deschloroclozapine is also a potent agonist for hM ₄ Di with an EC ₅₀ =0.081 nM.
Deschloroclozapine is a potent and selective agonist for hM _{3 Dq and hM 4 Di, it does not display significant agonistic activity for any of the 318 tests wild-type GPCRs at <10 nM.}