889797-65-3

DC_501 is a selective non-nucleoside inhibitor of DNA methyltransferase 1 (DNMT1).

DNMT1-IN-4 is a potent non-nucleoside DNA methyltransferase 1 (DNMT1) inhibitor with an IC50 value of 2.5 μM and selectivity towards other AdoMet-dependent protein methyltransferases. DNMT1-IN-4 significantly inhibits cancer cell proliferation[1].

[1] Chen S, ET AL. Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening. J Med Chem. 2014 Nov 13;57(21):9028-41. DOI:10.1021/jm501134e