87450-10-0

Propargyl-PEG5-alcohol enables Click Chemistry reactions with azide compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.

Propargyl-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In a three-necked flask equipped with a magnetic stirrer, a reflux condenser tube and a thermometer, 1.4 g of potassium tert-butoxide, 2.0 g of tetrapolyethylene glycol, 3.0 g of propargyl bromide and 95 mL of tetrahydrofuran were added respectively, prot

PEGs

[1] Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.