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3-Hydroxybenzonitrile, is an intermediate that can be used for the synthesis of new Serotonin 5-HT1A receptor agonists having antinociceptive activity in vivo.

The general procedure for the synthesis of 3-hydroxybenzonitrile from 3-cyanophenylboronic acid was as follows: arylboronic acid (1 mmol), 30% H2O2 aqueous solution (0.2 mL), ZnO nanocatalyst (5 mol%, sample ZnO-1), and 2 mL of water were mixed with stirring in a 50 mL round bottom flask at room temperature and under aerobic conditions. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was diluted with 20 mL of water and extracted with diethyl ether (3 x 20 mL). The organic layers were combined, washed with brine and dried over Na2SO4. Subsequently, the solvent was removed under reduced pressure in a rotary evaporator. The crude product was purified by silica gel (100-200 mesh) column chromatography (eluent: hexane/ethyl acetate, 9:1) to afford the target product 3-hydroxybenzonitrile. The structure of the product was confirmed by 1H NMR and 13C NMR.

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