871576-03-3

Name	TGN 255
CAS	871576-03-3
Molecular Formula	C27H36BN3O7
MDL Number	MFCD16038918
Molecular Weight	525.4
MOL File	871576-03-3.mol

Synonyms

TGN 255 Flovagatran PAOGOXGDGABPSC-SGNDLWITSA-N L-Prolinamide, N-[(phenylmethoxy)carbonyl]-D-phenylalanyl-N-[(1R)-1-borono-4-methoxybutyl]-

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Chemical Properties

density	1.237±0.06 g/cm3(Predicted)
pka	9.66±0.43(Predicted)

Hazard Information

Uses

Flovagatran (TGN 255) is a potent and reversible thrombin inhibitor (Ki: 9 nM). Flovagatran can be used in the research of arterial and venous thrombosis[1].

in vivo

Flovagatran (2.5-mg/kg bolus plus 10 mg/kg/h for 90 minutes) produces anticoagulation effects in dogs^[1].

Animal Model:	Chicks^[1]
Dosage:	1.0-mg/kg bolus and then 4 mg/kg/h for 90 minutes. 2.5-mg/kg bolus and then 10 mg/kg/h for 90 minutes. 5.0-mg/kg bolus and then 20 mg/kg/h for 90 minutes.
Administration:	Bolus plus infusion
Result:	Elevated PD markers, and produced minimal post-operative blood loss.

References

[1] Nelson DA, et al. Pharmacodynamic and efficacy profile of TGN 255, a novel direct thrombin inhibitor, in canine cardiopulmonary bypass and simulated mitral valve repair. J Extra Corpor Technol. 2008 Jun;40(2):116-22. PMID:18705547

Supplier

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Sangon Biotech (Shanghai) Co.,Ltd.

Telephone400-821-026

Websitehttp://www.sangon.com

Hu Bei Jiutian Bio-medical Technology CO.,Ltd

Telephone027-88013699 17354350817

Websitewww.jiutian-bio.com

Hangzhou MolCore BioPharmatech Co.,Ltd.

Telephone+86-057181025280; +8617767106207

Websitehttps://www.molcore.com/

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