866889-02-3

Thiol-PEG8-acid is a PEG linker containing a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

O-(2-Carboxyethyl)-O′-(2-mercaptoethyl)heptaethylene glycol can be used:

• To prepare near-infrared fluorochromes applicable in imaging techniques.
• To functionalize Au nanoparticles for optoelectronic applications.
• As a linker in the synthesis of antibody-functionalized Au nanoparticles for forensic applications.