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Quinofumelin is prepared through a short, convergent synthetic sequence that builds its fused quinoline–isoquinolinone framework. It begins with the construction of the difluoro substituted dihydroisoquinolinone fragment via cyclisation of a suitably substituted anilide under dehydrating conditions. In parallel, a halogenated quinoline precursor is generated through electrophilic substitution on a quinoline core. These two key fragments are then joined through a nucleophilic aromatic substitution that installs the isoquinolinone moiety onto the quinoline ring. Final steps involve purification, salt removal, and crystallisation to yield technical grade quinofumelin suitable for formulation.

Inhibits DHODH II (dihydroorotate dehydrogenase II)

Fungicide