85547-56-4

Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice^[1].
Piperaquine (90 mg/kg; a single i.p.) exhibits the t_1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg?h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg?h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice^[1].