850-52-2

Name	Altrenogest
CAS	850-52-2
EINECS(EC#)	212-703-1
Molecular Formula	C21H26O2
MDL Number	MFCD00867855
Molecular Weight	310.43
MOL File	850-52-2.mol

Chemical Properties

Melting point	120°
alpha	D20 -72° (c = 0.5 in ethanol)
Boiling point	390.58°C (rough estimate)
density	1.0865 (rough estimate)
refractive index	1.4900 (estimate)
storage temp.	0-6°C
solubility	DMF: 2 mg/ml; DMSO: 0.1 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
form	neat
pka	14.59±0.40(Predicted)
color	White to Yellow
Merck	14,319
InChI	InChI=1/C21H26O2/c1-3-10-21(23)12-9-19-18-6-4-14-13-15(22)5-7-16(14)17(18)8-11-20(19,21)2/h3,8,11,13,18-19,23H,1,4-7,9-10,12H2,2H3/t18-,19+,20+,21+/s3
InChIKey	VWAUPFMBXBWEQY-ANULTFPQSA-N
SMILES	C[C@]12C=CC3=C4CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@]2(O)CC=C \|&1:1,14,16,20,r\|

Safety Data

WGK Germany	3
RTECS	KG7745000
HS Code	2937.23.5050

Hazard Information

Chemical Properties

Pale Yellow Solid

Uses

A synthetic progestational agent used in veterinary medicine for the control of estrus in mares.

Uses

antineoplastic

Definition

ChEBI: Altrenogest is a 3-hydroxy steroid.

Brand name

REGUMATE (Roussel-UCLAF, France).

Side effects

People exposed to altrenogest products have potential health risks. Reproductive adverse effects reported in women and girls include abnormal or absent menstrual cycles, and in men include decreased libido. Other adverse effects reported after exposure include headaches, fever, abdominal pain, nausea, diarrhea, vomiting, and rashes.
Altrenogest causes essentially no side effects in mares, and it may be used for prolonged periods.

Veterinary Drugs and Treatments

Altrenogest (Regu-Mate?) is indicated (labeled) to suppress estrus in mares to allow a more predictable occurrence of estrus following withdrawal of the drug. It is used clinically to assist mares to establish normal cycles during the transitional period from anestrus to the normal breeding season often in conjunction with an artificial photoperiod. It is more effective in assisting in pregnancy attainment later in the transition period. Some authors (Squires et al. 1983) suggest selecting mares with considerable follicular activity (mares with one or more follicles 20 mm or greater in size) for treatment during the transitional phase. Mares that have been in estrus for 10 days or more and have active ovaries are also considered excellent candidates for progestin treatment.
Altrenogest is effective in normally cycling mares for minimizing the necessity for estrus detection, for the synchronization of estrus, and permitting scheduled breeding. Estrus will ensue 2 – 5 days after treatment is completed and most mares ovulate between 8 – 15 days after withdrawal. Altrenogest is also effective in suppressing estrus expression in show mares or mares to be raced. Although the drug is labeled as contraindicated during pregnancy, it has been demonstrated to maintain pregnancy in oophorectomized mares and may be of benefit in mares that abort due to sub-therapeutic progestin levels.
The product Matrix? is labeled for synchronization of estrus in sexually mature gilts that have had at least one estrous cycle. Treatment with altrenogest results in estrus (standing heat) 4-9 days after completion of the 14-day treatment period.
Altrenogest has been used in dogs for luteal insufficiency and as a treatment to prevent premature delivery.

Material Safety Data Sheet(MSDS)

Questions And Answer

Description
Altrenogest is used to suppress estrus in mares in order to facilitate induction of normal estrous cycle activity. It is also used in mares to synchronize scheduled breeding activity. In the suppression of estrous behavior in mares, this is usually related to mares that are used as performance horses.;
Application
Altrenogest is a progestin of the 19-nortestosterone group. As a veterinary medication, it is used extensively in the reproductive management of mares to control the reproductive cycle, help maintain pregnancy, and help with behavior modification. Altrenogest has been demonstrated to maintain pregnancy in oophorectomized mares and may be of benefit in mares that abort due to subtherapeutic progestin levels. Altrenogest is typically administered orally by applying directly on the base of the mare’s tongue or on the mare’s feed.;
Uses
Altrenogest is used for suppression of estrus. The mare will experience a predictable occurrence of estrus following drug withdrawal. This allows a regular cycle during the transition from winter anestrus to the physiological breeding season in mares with active ovaries. By managing the reproductive cycle, horse owners have more control over breeding procedures and the timing of the arrival of foals.;
Biological Activity
Altrenogest suspension by NexGen is effective in normally cycling mares for minimizing the necessity for estrus detection, for the synchronization of estrus, and permitting scheduled breeding. Altrenogest is also effective in suppressing estrus expression in show mares or mares to be raced.;
Interactions
Rifampin may increase the speed of metabolism of Regu-Mate.;
in vitro
Altrenogest (Allyltrenbolone) is a progestogen structurally related to veterinary steroid trenbolone. Treatment of embryo-recipient mares with Altrenogest (Allyltrenbolone) appears to be beneficial in extending the degree of donor-recipient synchrony required for successful embryo transfer. The oil and gel Altrenogest (Allyltrenbolone) preparations are equally effective in modulating estrous behavior and time to estrus and ovulation. Altrenogest (Allyltrenbolone) treatment started late in diestrus appears to result in a high incidence of ovulation during treatment and when luteolysis and ovulation occur during treatment; the subsequent luteal phase is frequently prolonged due to failure of regression of the CL.
;

Spectrum Detail

Supplier

Hubei widely chemical technology Co., Ltd.

Telephone027-83991130 18627774460

Websitehttp://www.widelychemical.com

CHENGHUI PHARMACEUTICAL GROUP LTD

Telephone0531-58897070 15254140813

Websitehttp://www.jnchsd.com/

Shanghai Jinli Pharmaceutical Co.,Ltd.

Telephone+86-021-57256005 +86-15921811235

Websitehttps://www.shjlchem.com/

J & K SCIENTIFIC LTD.

Telephone010-82848833 400-666-7788

Websitehttp://www.jkchemical.com

TCI (Shanghai) Development Co., Ltd.

Telephone021-67121386

Websitehttps://www.tcichemicals.com/CN/zh/

JinYan Chemicals(ShangHai) Co.,Ltd.

Telephone13817811078

Websitehttp://www.jingyan-chemical.com/

Nanjing Chemlin Chemical Co., Ltd

Telephone025-83697070

Websitehttp://www.echemlin.cn

Shanghai Hanhong Scientific Co.,Ltd.

Telephone021-54306202 13764082696;

Websitehttps://www.hanhongsci.com

Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

XiaoGan ShenYuan ChemPharm co,ltd

Telephone0712-0712-2580635 15527768850

Websitehttp://www.farchem.com/

Jinan Chenghui Shuangda biological Co., LTD

Telephone0531-58897003 15550412551

Websitehttp://www.jnchsd.com

Tianjin heowns Biochemical Technology Co., Ltd.

Telephone400 638 7771

Websitehttp://www.heowns.com

Shanghai Everchem Co., Ltd

Telephone86-29-81325371

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList5555/0.htm

Hangzhou Yuhao Chemical Technology Co., Ltd

Telephone0571-82693216

Websitehttp://www.chemyuhao.com

Beijing Taiya Jie Technology Development Co., Ltd.

Telephone021-33690831-8001 13552411790

Websitehttp://www.tyj-chem.com/

Wuhan Fortuna Chemical Co., Ltd

Telephone027-027-59207852 13308628970

Websitehttp://www.fortunachem.cn

BioBioPha Co., Ltd.

Telephone0871-65217109 13211707573;

Websitehttp://www.biobiopha.com

Shanghai T&W Pharmaceutical Co., Ltd.

Telephone+86 21 61551611

Websitehttp://www.trustwe.com

1of4

Related Products

Send Inquriy

850-52-2

Chemical Properties

Safety Data

Hazard Information

Chemical Properties

Uses

Uses

Definition

Brand name

Side effects

Veterinary Drugs and Treatments

Material Safety Data Sheet(MSDS)

Questions And Answer

Description

Application

Uses

Biological Activity

Interactions

in vitro

Spectrum Detail

Supplier

Related Products