ChemicalBook CAS DataBase List 85-61-0

85-61-0

Name	Coenzyme A
CAS	85-61-0
EINECS(EC#)	201-619-0
Molecular Formula	C21H36N7O16P3S
MDL Number	MFCD06795839
Molecular Weight	767.54
MOL File	85-61-0.mol

Chemical Properties

Appearance	yellowish lyophilisate
density	1.96±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	PBS (pH 7.2): 10 mg/ml
form	A crystalline solid
pka	9.6 (thiol); pK 6.4 (secondary phosphate); pK 4.0 (adenine NH3+)
color	White to light yellow
biological source	yeast
Merck	13,2491
BRN	77809
Cosmetics Ingredients Functions	SKIN CONDITIONING
InChIKey	RGJOEKWQDUBAIZ-IBOSZNHHSA-N
SMILES	SCCNC(=O)CCNC(=O)[C@@H](C(COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](N2C3N=CN=C(N)C=3N=C2)[C@H](O)[C@@H]1OP(=O)(O)O)(C)C)O
LogP	-4.358 (est)
EPA Substance Registry System	Coenzyme A(85-61-0)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H315-H335
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Safety Statements	24/25 less more
WGK Germany	3
F	1-10
TSCA	Yes
HS Code	2933299090
Storage Class	11 - Combustible Solids

Raw materials And Preparation Products

Hazard Information

Chemical Properties

yellowish lyophilisate

Description

Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. About 4% of cellular enzymes utilize CoA as a substrate. It is synthesized from pantothenic acid in a 5-step process that requires ATP. The pantothenate kinase step of the CoA biosynthetic pathway has been identified as a target for the development of antibacterial compounds.

Uses

A hydrated form of Coenzyme A (CoA) is a useful biochemical research chemical, used in the preparation of high-yielding cell-free protein synthesis platforms.

Definition

ChEBI: Tetraanion of coenzyme A.

General Description

Coenzyme A is structurally composed of 2-aminoethanethiol, pantothenic acid and phosphorylated adenosine phosphate.

Biochem/physiol Actions

Coenzyme A is a cofactor involved in acyl group transfer. It is essential for carbohydrate, lipid and protein metabolism. Coenzyme A acts as a cofactor for vitamin B coenzymes.

Purification Methods

The white powder is best stored in an inert atmosphere in the dark in sealed ampoules after drying in vacuo over P2O5 at 34o. It has UV: max 259 nm ( 16,800) in H2O. [Buyske et al. J Am Chem Soc 76 3575 1954.] It is soluble in H2O but insoluble in EtOH, Et2O and M2CO. It is readily oxidised in air and is best kept as the more stable trilithium salt [Moffat & Khorana J Am Chem Soc 83 663 1961; see also Beinert et al. J Biol Chem 200 384 1953, De Vries et al. J Am Chem Soc 72 4838 1950, Gregory et al. J Am Chem Soc 74 854 1952 and Baddiley Adv Enzymol 16 1 1955]. [Beilstein 26 III/IV 3663.]

References

[1] ROBERTA LEONARDI. Coenzyme A: Back in action[J]. Progress in lipid research, 2005, 44 2: Pages 125-153. DOI: 10.1016/j.plipres.2005.04.001
[2] BROWN G M. Biosynthesis of Pantothenic Acid and Coenzyme A[J]. Comprehensive Biochemistry, 1900, 168 1: 0. DOI: 10.1016/b978-0-444-40871-6.50012-x
[3] T. BEGLEY E S C Kinsland. The biosynthesis of coenzyme A in bacteria.[J]. Vitamins and Hormones, 2001, 20 1: 157-171. DOI: 10.1016/s0083-6729(01)61005-7

Material Safety Data Sheet(MSDS)

Spectrum Detail

Supplier

Hubei XinghengKang Chemical Technology Co., Ltd.

Telephone027-88878869 18162384755

Websitehttp://www.xhkhgkj.com/

Hubei Lingyan Biotechnology Co., Ltd

Telephone027-59304846 13297025796

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList826010/0_EN.htm

Suizhou HongQi Chemical Corporation Limited

Telephone0722-3257376 13026100080;13235518175;

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList15863/0_EN.htm

Nanjing Sunlida Biological Technology Co., Ltd.

Telephone025-57798810 18652991625

Website

Hubei deante Chemical Technology Co., Ltd

Telephone 15927262683

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList573207/0_EN.htm

Suizhou Jiake Biological Engineering Co., Ltd.

Telephone0722-3632989 18008664499

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList31346/0_EN.htm

Hubei Zhengxingyuan Fine Chemical Co., Ltd.

Telephone027-027-87879189 15207106154

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList946892/0_EN.htm

Xinxiang Yicheng Biotechnology Co.,LTD

Telephone0373-5799336 18937330588

Websitehttp://www.xxycsw.com

Shanghai Richuan Biotechnology Co., Ltd.

Telephone 18930985832

Website

Chembest Research Laboratories Limited

Telephone021-20908456

Websitehttp://www.BioChemBest.com

Beijing HwrkChemical Technology Co., Ltd

Telephone89508211 18501085097

Websitehttp://www.hwrkchemical.com

Energy Chemical

Telephone021-021-58432009 400-005-6266

Websitehttp://www.energy-chemical.com

Beijing Ouhe Technology Co., Ltd

Telephone13552068683 13522913783

Websitehttp://www.ouhetech.cn/

Adamas Reagent, Ltd.

Telephone400-6009262 15618770481

Websitehttp://www.tansoole.com

Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

Shandong Xiya Chemical Co., Ltd

Telephone13355009207 13355009207

Websitehttp://www.xiyashiji.com

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Telephone0731-85526065 13308475853

Websitehttp://www.hnhbsj.com/

Dalian Meilun Biotech Co., Ltd.

Telephone0411-62910999 13889544652

Websitehttp://www.meilunbio.com/

1of4

Related Products

Send Inquriy