ChemicalBook CAS DataBase List 826-36-8

826-36-8

Name	Triacetonamine
CAS	826-36-8
EINECS(EC#)	212-554-2
Molecular Formula	C9H15NO3
MDL Number	MFCD00005975
Molecular Weight	185.22
MOL File	826-36-8.mol

Synonyms

2,2,6,6-TETRAMETHYL-4-PIPERIDINONE 2,2,6,6-TETRAMETHYL-4-PIPERIDONE 2,2,6,6-TETRAMETHYL-PIPERIDIN-4-ONE 2,2,6,6-TETRAMETHYLTETRAHYDRO-4(1H)-PYRIDINONE LABOTEST-BB LT00159409 TAA TETRAMETHYLPIPERIDINONE TRIACETONAMINE TRIACETONEAMINE 2,2,6,6-Tetramethyl-4-oxopiperidine 2,2,6,6-tetramethyl-4-piperidinon 2,2,6,6-tetramethyl-4-piperidon 2,2,6,6-Tetramethylpiperidinone 2,2,6,6-Tetramethylpiperidone 4-Oxo-2,2,6,6-tetramethylpiperidine 4-Piperidinone,2,2,6,6-tetramethyl- 4-Piperidone, 2,2,6,6-tetramethyl- 4-Piperidone,2,2,6,6-tetramethyl- Ikh 196 IKh196

Chemical Properties

Appearance	white crystalline powder
Melting point	59-61 °C
Boiling point	105-105°C/18mm
density	0.9796 (rough estimate)
refractive index	1.4680 (estimate)
Fp	73°C
storage temp.	Refrigerator (+4°C)
solubility	DMSO, Methanol
form	Solid
pka	9.20±0.60(Predicted)
color	Pale Orange to Light Brown Low Melting
Water Solubility	249g/L at 20℃
InChI	1S/C9H17NO/c1-8(2)5-7(11)6-9(3,4)10-8/h10H,5-6H2,1-4H3
InChIKey	JWUXJYZVKZKLTJ-UHFFFAOYSA-N
SMILES	CC1(C)CC(=O)CC(C)(C)N1
LogP	1.32 at 25℃
CAS DataBase Reference	826-36-8(CAS DataBase Reference)
NIST Chemistry Reference	4-Piperidinone, 2,2,6,6-tetramethyl-(826-36-8)
EPA Substance Registry System	826-36-8(EPA Substance)

Safety Data

Symbol(GHS)	GHS05,GHS07
Signal word	Danger
Hazard statements	H290-H302-H314-H317-H412
Precautionary statements	P260-P273-P280-P301+P330+P331-P303+P361+P353-P305+P351+P338
Hazard Codes	C,Xn
Risk Statements	R34:Causes burns. R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S22:Do not breathe dust . S36/37:Wear suitable protective clothing and gloves . less more
WGK Germany	2
RTECS	TO0127900
TSCA	TSCA listed
REACH Registrations	Active
HS Code	29333990
Storage Class	8B - Non-combustible corrosive hazardous materials
Hazard Classifications	Acute Tox. 4 Oral Aquatic Chronic 3 Eye Dam. 1 Met. Corr. 1 Skin Corr. 1B Skin Sens. 1A

Hazard Information

Definition

ChEBI: Triacetonamine is a member of piperidones.

Synthesis Reference(s)

Synthesis, p. 735, 1976 DOI: 10.1055/s-1976-24178

Synthesis

The routes of triacetonamine synthesis includes^[1]:
a. From acetone and ammonia. Triacetonamine was initially prepared by the method of Francisfrom acetone and ammonia in the presence of an acidic catalyst like calcium chloride in a 20% yield. Co-catalysts bromine or iodine combined with acid halides of the type XCH2COX acted as synergists.
b. From phorone and ammonia. Phorone reacted with ammonia to give triacetonamine via the nucleophilic addition of nitrogen to the olefi nic bond.
c. From N-oxides. Triacetonamine was formed via reduction of cation in the presence of NaOH in acetone media.
d. From alcohols. Photogenerated singlet oxygen was used in oxidation of alcohol with formation of triacetonamine under mild and facile conditions using the catalyst CoIIDPDME.
e. From dimethylamine derivatives. Dimethylamine was alkylated by methyl iodide. The following hydrolysis gave triacetonamine.

in vivo

Triacetonamine (Purchased from MCE; 200 mg, 300 mg, 400 mg/Kg/day; gavage; 2 days) shows typical hepatoenteropathology of ALF with 300 mg/Kg/day and 400 mg/Kg/day, while the group of 400 mg/Kg/day had higher mortality^[2].

Animal Model:	Rats (half male and female, 6-8 weeks old, 200?±?10 g)^[2]
Dosage:	200 mg, 300 mg, 400 mg/Kg
Administration:	Gavage; daily; 2 days
Result:	Showed typical hepatoenteropathology of ALF with 300 mg/Kg/day and 400 mg/Kg/day, while the group of 400 mg/Kg/day had higher mortality.

References

[1] Yousif, M. N. M., Soliman, H. A., Said, M. M., Hassan, N. A., & Abdel-Megeid, F. M. E. (2020). Synthesis and Biological Activity of Triacetonamine. Russian Journal of General Chemistry, 90 3, 460–469. https://doi.org/10.1134/S1070363220030202

Material Safety Data Sheet(MSDS)

Questions And Answer

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

Chongqing Yuanyuanxiang Technology Development Co. LTD

Telephone023-55703781 15320534687

Websitehttps://www.chemicalbook.com/supplier/23615899/

Hubei Shiteng Chemical Technology Co. LTD

Telephone19086915685 18971850150

Websitehttps://www.chemicalbook.com/supplier/15553011/1.htm

Henan Guosheng Chemical Co., Ltd

Telephone 17610068021

Website

Shandong Puyitai new material Co., LTD

Telephone0530-2363311 17560588657

Websitehttps://www.polytai.com

Nanjing Hike Biological Technology.,ltd

Telephone025-52110956 17372769668

Websitehttps://www.njhkchem.com

Nantong Provikon Biotechnology Co., Ltd

Telephone 17505220108

Websitehttp://www.provichem.cn

J & K SCIENTIFIC LTD.

Telephone18210857532 18210857532

Websitehttps://www.jkchemical.com

Meryer (Shanghai) Chemical Technology Co., Ltd.

Telephone4006356688 18621169109

Websitehttp://www.x-labseek.com/

Chembest Research Laboratories Limited

Telephone021-20908456

Websitehttp://www.BioChemBest.com

TCI (Shanghai) Development Co., Ltd.

Telephone021-67121386

Websitehttps://www.tcichemicals.com/CN/zh/

Energy Chemical

Telephone 400-0056266

Websitehttp://www.energy-chemical.com

Beijing Ouhe Technology Co., Ltd

Telephone13552068683 13522913783

Websitehttp://www.ouhetech.cn/

Nanjing Chemlin Chemical Co., Ltd

Telephone025-83697070 13770331960

Websitehttp://www.echemlin.cn

Shanghai Hanhong Scientific Co.,Ltd.

Telephone021-54306202 13764082696

Websitehttps://www.hanhongsci.com

Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

XiaoGan ShenYuan ChemPharm co,ltd

Telephone15527621225; 15527621225

Websitehttp://www.farchem.com/

Syntechem Co.,Ltd

Telephone

Websitehttp://www.syntechem.com/

Sichuan Kulinan Technology Co., Ltd

Telephone400-1166-196 18981987031

Websitehttp://www.hx-r.com/

1of4

Related Products

Send Inquriy

826-36-8

Chemical Properties

Safety Data

Hazard Information

Definition

Synthesis Reference(s)

Synthesis

in vivo

References

Material Safety Data Sheet(MSDS)

Questions And Answer

Triacetone amine

Chemical Properties

Uses

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

Related Products