ChemicalBook CAS DataBase List 81627-83-0

81627-83-0

Name	HUMAN M-CSF
CAS	81627-83-0
MDL Number	MFCD00241918

Chemical Properties

storage temp.	-20°C
form	lyophilized powder
color	white to off-white
biological source	rat

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36/37/38 less more
Safety Statements	22-24/25-26 less more
WGK Germany	3
RTECS	GI5500000
Storage Class	11 - Combustible Solids

Hazard Information

Uses

Macrophage Colony-Stimulating Factor from mouse has been used:

in the initiation of osteoclastogenesis in bone marrow monocyte cells
to stimulate osteoclast differentiation in non-adherent hematopoietic cell
for the generation of blood-derived stem cells

Uses

Antineoplastic; anti-infective growth factor that acts on both progenitor and mature cells of the macrophage line.

General Description

M-CSF (macrophage colony-stimulating factor) is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. The protein works through its receptor CSF1R (colony stimulating factor 1 receptor). The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4kDa homodimeric protein containing two 156 amino acid polypeptide subunits.

Biochem/physiol Actions

M-CSF (macrophage colony-stimulating factor) is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. M-CSF also works as a pleiotropic growth factor and plays a crucial role in reproduction and organogenesis. Absence of it can result in reduced growth, neurological and reproductive problems, developmental defects in the mammary gland, bone and pancreas. M-CSF is also involved in the pathogenesis of cancer.

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