Hazard Information
Description
Psoriasis is a chronic inflammatory skin disorder that affects approximately 2-3% of the world’s population. The most common form of the
disease is plaque psoriasis, which is a result of dysregulated cell growth.
Conventional treatment options for psoriasis include topical corticosteroids, phototherapy, and systemic drugs (oral retinoids, cyclosporine, and
MTX), but all of these therapies have limitations.
Ustekinumab
is the latest biologic to be approved for the treatment of plaque psoriasis.
It is a human IgG1k monoclonal antibody that binds with high affinity and specificity to the p40 protein subunit used by both the interleukin-12
(IL-12) and interleukin-23 (IL-23) cytokines. IL-12 and IL-23 are naturally
occurring cytokines that are involved in inflammatory and immune
responses, such as NK cell activation and CD4+ T-cell differentiation
and activation. In in vitro models, ustekinumab is shown to disrupt IL12- and IL-23-mediated signaling and cytokine cascades by disrupting the
interaction of these cytokines with a shared cell-surface receptor chain,
IL-12?1. Ustekinumab is indicated for the treatment of adult patients (18
years or older) with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy.
Adverse events associated with the use of ustekinumab included nasopharyngitis, upper respiratory tract infection, headache, fatigue, and diarrhea.
Adverse events associated with the use of ustekinumab included nasopharyngitis, upper respiratory tract infection, headache, fatigue, and diarrhea.
Originator
Medarex (US)
Uses
Ustekinumab is used to treat plaque psoriasis, a certain type of arthritis or certain bowel conditions.
Brand name
Stelara
Supplier
Shanghai Boyle Chemical Co., Ltd.
Telephone
Websitehttp://www.boylechem.com
Shanghai Fuhe Chemistry Technology Co., Ltd.
Telephone0086-21-67651709
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList15402/0.htm
Wuhan Fortuna Chemical Co., Ltd
Telephone027-027-59207852 13308628970
Websitehttp://www.fortunachem.cn
Dalian Meilun Biotech Co., Ltd.
Telephone0411-62910999 13889544652
Websitehttp://www.meilune.com/
Sichuan Wei Keqi Biological Technology Co., Ltd.
Telephone028-81700200 18116577057
Websitehttp://www.weikeqi-biotech.com
Taizhou KEDE Chemical Co., Ltd
Telephone0576-84613060 13093829633
Websitehttp://www.kedechemical.com
Shanghai Lollane Biological Technology Co.,Ltd.
Telephone021-52996696,15000506266 15000506266
Websitehttp://www.bioll.com
Shanghai Hanjing Chemicals Co., Ltd.
Telephone021-54285032 13641685631
Websitehttp://www.hanjingchemicals.com
Shanghai EFE Biological Technology Co., Ltd.
Telephone021-65675885 18964387627
Websitehttp://www.efebio.com
ShangHai Biochempartner Co.,Ltd
Telephone17754423994 17754423994
Websitehttps://www.biochempartner.com
Shanghai Rechem science Co., Ltd.
Telephone21-31433387 15618786686
Websitehttp://cn.rechemscience.com
Hefei Hirisun Pharmatech Co., Ltd.
Telephone+86-0551-62678551 +86-15056975894
Websitehttp://www.hirisunpharm.com
Wellman Pharmaceutical Group Limited
Telephone027-027-83778875 15807197853
Websitehttps://www.4008081911.com
Twochem Co.Ltd.
Telephone021-58111628 15800915896
Websitehttp://cn.twochem.com
Fan De(Beijing) Biotechnology Co., Ltd.
Telephone 15911056312
Websitehttp://www.bio-fount.com/
Taizhou Crene Biotechnology Co. Ltd.
Telephone0576-88813233 13396860566
Websitehttp://www.pharm-intermediates.com
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Telephone18081075745
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList31177/0.htm
Hefei TNJ Chemical Industry Co.,Ltd.
Telephone0551-65418684 +8618949823763
Websitehttps://www.tnjchem.com
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