Hazard Information
Description
Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.
Biological Activity
Atezolizumab inhibits proliferation and induces immune independent apoptosis of osteosarcoma cells. The proliferation of HOS and 143B both were inhibited by atezolizumab in a dose-dependent manner. The IC50 values of HOS and 143B were between 10-20 μg/ml. Atezolizumab treatment reduces endotoxin levels and intestinal mucosal permeability as well as decreases ileum histological scores in septic mice. However, atezolizumab treatment increases the expression of tight junction proteins in the ileum during sepsis.
Uses
Atezolizumab is an FDA-approved targeted therapy drug. It is a monoclonal antibody that works by binding to PD-L1, a protein on the surface of certain cancer cells, thus preventing the cancer cells from suppressing the immune system. This allows the immune system to attack and kill the cancer cells. Atezolizumab is approved for use alone or with other drugs to treat Alveolar soft part sarcoma, Hepatocellular carcinoma, Melanoma, Non-small cell lung cancer and Small cell lung cancer.
Questions And Answer
-
Biological Activity
Atezolizumab inhibits proliferation and induces immune independent apoptosis of osteosarcoma cells. The proliferation of HOS and 143B both were inhibited by atezolizumab in a dose-dependent manner. The IC50 values of HOS and 143B were between 10-20 μg/ml. Atezolizumab treatment reduces endotoxin levels and intestinal mucosal permeability as well as decreases ileum histological scores in septic mice. However, atezolizumab treatment increases the expression of tight junction proteins in the ileum during sepsis.;
Supplier
Hubei Zhongshan Medical Technology Co., Ltd
Telephone027-61907345 13397111514
Websitehttp://www.hbzsfx.com/
Hefei Hirisun Pharmatech Co., Ltd.
Telephone+86-0551-62678551 +86-15056975894
Websitehttp://www.hirisunpharm.com
Chembest Research Laboratories Limited
Telephone+86-21-20908456
Websitehttp://www.BioChemBest.com
Wuhan Fortuna Chemical Co., Ltd
Telephone027-59207852 13308628970
Websitehttp://www.fortunachem.cn
Dalian Meilun Biotech Co., Ltd.
Telephone0411-62910999 13889544652
Websitehttp://www.meilune.com/
Nanjing Sunlida Biological Technology Co., Ltd.
Telephone025-57798810
Websitehttp://www.sunlidabio.com
Taizhou KEDE Chemical Co., Ltd
Telephone0576-84613060 13093829633
Websitehttp://www.kedechemical.com
Shanghai Lollane Biological Technology Co.,Ltd.
Telephone021-52996696，15000506266 15000506266
Websitehttp://www.bioll.com
Shanghai Hanjing Chemicals Co., Ltd.
Telephone021-54285032 13641685631
Websitehttp://www.hanjingchemicals.com
ShangHai Biochempartner Co.,Ltd
Telephone177-54423994 17754423994
Websitehttps://www.biochempartner.com
Shanghai Rechem science Co., Ltd.
Telephone21-31433387 15618786686
Websitehttp://cn.rechemscience.com
Beijing Jin Ming Biotechnology Co., Ltd.
Telephone010-60605840 18892239720
Websitehttp://www.jm-bio.com/
Wellman Pharmaceutical Group Limited
Telephone027-83778875 15807197853
Websitehttps://www.4008081911.com
Chemleader Biomedical Co., Limited.
Telephone021-58180488
Websitehttp://www.Medchemleader.cn
Twochem Co.Ltd.
Telephone021-58111628 15800915896
Websitehttp://cn.twochem.com
Fan De(Beijing) Biotechnology Co., Ltd.
Telephone 15911056312
Websitehttp://www.bio-fount.com/
Taizhou Crene Biotechnology Co. Ltd.
Telephone+86-0576-88813233 +86-13396860566
Websitehttp://www.pharm-intermediates.com
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Telephone18081075745
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList31177/0.htm
1of4
PROMPT×
PROMPT
The What'sApp is temporarily not supported in mainland China
The What'sApp is temporarily not supported in mainland China
Cancel
Determine