Hazard Information
Description
Ipilimumab is a CTLA-4 blocking antibody that was approved by the
U.S. FDA in March 2011 for the treatment of unresectable or metastatic
melanoma. Therefore, ipilimumab has an indirect effect on tumors that is
mediated through blockade of CTLA-4 negative signaling and
augmentation of T-cell activity. It is one of a handful of
immunostimulatory drugs (e.g., aldesleukin and interferon alfa-2b) now approved for cancer therapy.
Originator
Bristol-Myers Squibb (United States)
Uses
Treatment of
oncology disease and HIV infection.
Brand name
Yervoy
Clinical Use
Antineoplastic agent:
Treatment of advanced (unresectable or metastatic) melanoma in adults who have received prior therapy
Treatment of advanced (unresectable or metastatic) melanoma in adults who have received prior therapy
Drug interactions
Potentially hazardous interactions with other drugs
Live vaccines: risk of generalised infections - avoid.
Live vaccines: risk of generalised infections - avoid.
Metabolism
Most likely removed by opsonisation via the
reticuloendothelial system when bound to T lymphocytes,
or by human antimurine antibody production.
Supplier
Dalian Meilun Biotech Co., Ltd.
Telephone0411-62910999 13889544652
Websitehttp://www.meilune.com/
NCE Biomedical Co.,Ltd.
Telephone4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList15748/0.htm
Sichuan Wei Keqi Biological Technology Co., Ltd.
Telephone028-81700200 18116577057
Websitehttp://www.weikeqi-biotech.com
Taizhou KEDE Chemical Co., Ltd
Telephone0576-84613060 13093829633
Websitehttp://www.kedechemical.com
LETOPHARM LIMITED
Telephone+86-21-5821 5861
Websitehttp://www.letopharm.com
Shanghai Lollane Biological Technology Co.,Ltd.
Telephone021-52996696,15000506266 15000506266
Websitehttp://www.bioll.com
Watson Biotechnology Co.,Ltd
Telephone027-027-59207879 18140587686
Websitehttp://www.watsonbiotech.cn
Shanghai Hanjing Chemicals Co., Ltd.
Telephone021-54285032 13641685631
Websitehttp://www.hanjingchemicals.com
Shanghai EFE Biological Technology Co., Ltd.
Telephone021-65675885 18964387627
Websitehttp://www.efebio.com
Shanghai Shanyuan pharmaceutical technology co., LTD
Telephone021-31761238 13167072949
Websitehttp://www.saferph.com
ShangHai Biochempartner Co.,Ltd
Telephone17754423994 17754423994
Websitehttps://www.biochempartner.com
Shanghai Rechem science Co., Ltd.
Telephone21-31433387 15618786686
Websitehttp://cn.rechemscience.com
Hefei Hirisun Pharmatech Co., Ltd.
Telephone+86-0551-62678551 +86-15056975894
Websitehttp://www.hirisunpharm.com
Wellman Pharmaceutical Group Limited
Telephone027-027-83778875 15807197853
Websitehttps://www.4008081911.com
Guangdong wengjiang Chemical Reagent Co., Ltd.
Telephone0751-2815688 13927872512
Websitehttp://www.wj-chem.com
Taizhou Crene Biotechnology Co. Ltd.
Telephone0576-88813233 13396860566
Websitehttp://www.pharm-intermediates.com
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Telephone18081075745
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList31177/0.htm
Wuhan Golt Biotech Co., Ltd.
Telephone +8615389281203
Websitewww.goltbiotech.com
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