790663-33-1

PBD-150 (790663-33-1) is an inhibitor of human glutaminyl cyclase (IC50 = 60 nM).1 PBD-150 diminished Ab plaque formation and gliosis while improving memory in a mouse model with small amounts of Ab3(pE)-40/42.2

PBD-150 is a human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor, with a Ki value of 490 nM[1][2].

Buchholz et al. (2006), The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship; J. Med. Chem., 49 664 Schilling et al. (2008), Glutaminyl cyclase inhibition attenuates pyroglutamate Ab and Alzheimer’s disease-like pathology; Nat. Med., 14 1106